Smad2 and Smad4 gene mutations in hepatocellular carcinoma

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dc.citation.epage4883en_US
dc.citation.issueNumber34en_US
dc.citation.spage4879en_US
dc.citation.volumeNumber18en_US
dc.contributor.authorYakicier, M. C.en_US
dc.contributor.authorIrmak, M. B.en_US
dc.contributor.authorRomano, A.en_US
dc.contributor.authorKew, M.en_US
dc.contributor.authorOzturk, M.en_US
dc.date.accessioned2016-02-08T10:41:06Z
dc.date.available2016-02-08T10:41:06Z
dc.date.issued1999en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractTGF-β is a negative regulator of liver growth. Smad family of genes, as mediators of TGF-β pathway, are candidate tumor suppressor genes in hepatocellular carcinoma (HCC). We studied 35 HCC and non-tumour liver tissues for possible mutations in Smad2 and Smad4 genes. Three tumours displayed somatic mutations; two in Smad4 (Asp332Gly and Cys401Arg) and one in Smad2 (Gln407Arg) genes. All three mutations were A:T → G:C transitions suspected to result from oxidative stress as observed in mitochondrial DNA. These observation demonstrate that TGF-β pathway is altered in hepatocellular carcinoma.en_US
dc.identifier.doi10.1038/sj.onc.1202866en_US
dc.identifier.issn0950-9232
dc.identifier.urihttp://hdl.handle.net/11693/25217
dc.language.isoEnglishen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/sj.onc.1202866en_US
dc.source.titleOncogeneen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectSmad2en_US
dc.subjectSmad4en_US
dc.subjectSomatic mutationen_US
dc.subjectTGFβen_US
dc.subjectTumor suppressor genesen_US
dc.subjectMitochondrial DNAen_US
dc.titleSmad2 and Smad4 gene mutations in hepatocellular carcinomaen_US
dc.typeArticleen_US
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