Nanoengineering InP quantum dot-based photoactive biointerfaces for optical control of neurons

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buir.contributor.authorUlgut, Burak
buir.contributor.orcidUlgut, Burak|0000-0002-4402-0033
dc.citation.epage652608/14en_US
dc.citation.spage652608/1en_US
dc.citation.volumeNumber15en_US
dc.contributor.authorKaratum, O.
dc.contributor.authorAria, M. M.
dc.contributor.authorEren, G. Ö.
dc.contributor.authorYıldız, E.
dc.contributor.authorMelikov, R.
dc.contributor.authorSrivastava, S. B.
dc.contributor.authorSürme, S.
dc.contributor.authorBakış Doğru, I.
dc.contributor.authorJalali, H. B.
dc.contributor.authorUlgut, Burak
dc.contributor.authorŞahin, A.
dc.contributor.authorKavaklı, İ. H.
dc.contributor.authorNizamoğlu, S.
dc.date.accessioned2022-02-15T11:50:52Z
dc.date.available2022-02-15T11:50:52Z
dc.date.issued2021-06-23
dc.departmentDepartment of Chemistryen_US
dc.description.abstractLight-activated biointerfaces provide a non-genetic route for effective control of neural activity. InP quantum dots (QDs) have a high potential for such biomedical applications due to their uniquely tunable electronic properties, photostability, toxic-heavy-metal-free content, heterostructuring, and solution-processing ability. However, the effect of QD nanostructure and biointerface architecture on the photoelectrical cellular interfacing remained unexplored. Here, we unravel the control of the photoelectrical response of InP QD-based biointerfaces via nanoengineering from QD to device-level. At QD level, thin ZnS shell growth (∼0.65 nm) enhances the current level of biointerfaces over an order of magnitude with respect to only InP core QDs. At device-level, band alignment engineering allows for the bidirectional photoelectrochemical current generation, which enables light-induced temporally precise and rapidly reversible action potential generation and hyperpolarization on primary hippocampal neurons. Our findings show that nanoengineering QD-based biointerfaces hold great promise for next-generation neurostimulation devices.en_US
dc.identifier.doi10.3389/fnins.2021.652608en_US
dc.identifier.eissn1662-453X
dc.identifier.urihttp://hdl.handle.net/11693/77381
dc.language.isoEnglishen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.isversionofhttps://doi.org/10.3389/fnins.2021.652608en_US
dc.source.titleFrontiers in Neuroscienceen_US
dc.subjectBiointerfaceen_US
dc.subjectNeuromodulationen_US
dc.subjectPhotostimulationen_US
dc.subjectQuantum doten_US
dc.subjectIndium phosphideen_US
dc.subjectNanocrystalen_US
dc.subjectNeural interfaceen_US
dc.subjectNanoengineeringen_US
dc.titleNanoengineering InP quantum dot-based photoactive biointerfaces for optical control of neuronsen_US
dc.typeArticleen_US
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