A diffusion tensor imaging study in schizophrenia patients with clozapine induced obsessive compulsive symptoms

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buir.contributor.authorHas, Arzu Ceylan
buir.contributor.orcidhttps://orcid.org/0000-0003-4346-3366
dc.citation.epage13en_US
dc.citation.issueNumber1en_US
dc.citation.spage1en_US
dc.citation.volumeNumber38en_US
dc.contributor.authorBıçakçı Ay, Ş.
dc.contributor.authorÖzçelik Eroğlu, E.
dc.contributor.authorHas, Arzu Ceylan
dc.contributor.authorErtuğrul, A.
dc.contributor.authorOğuz, Kader K.
dc.date.accessioned2023-02-15T06:50:59Z
dc.date.available2023-02-15T06:50:59Z
dc.date.issued2022-11-16
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.description.abstractObjective The aim of this study was to evaluate brain connectivity by diffusion tensor imaging (DTI) in schizophrenia patients with clozapine-induced obsessive compulsive symptoms (OCS). Methods Eighteen schizophrenia patients, nine of which had clozapine-induced OCS (Clz-OCS (+)), 9 without OCS (Clz-OCS (−)) and 9 healthy controls were included. Psychopathology was evaluated with Positive and Negative Syndrome Scale and Yale-Brown Obsession and Compulsion Scale in the patient groups. All groups were assesed with neurocognitive tests and DTI. Results Tract-Based Spatial Statistics based comparison of DTI revealed lower fractional anisotropy in the genu of corpus callosum (CC), right cingulum, left frontal white matter (WM) in the Clz-OCS (+) group, compared to controls. Fractional anisotropy was found to be lower in the bilateral occipital WM and higher in the bilateral medial temporal regions, anterior limb of internal capsule, cingulum, frontoparietal peripheral WM, right external capsule and genu of CC in Clz-OCS (+) patients compared to Clz-OCS (−). Conclusions WM integrity in several pathways such as cortico-striato-thalamo-cortical circuitry and orbito-frontal tracts seems to be affected differently in patients with Clz-OCS (+). Different neuroplastic effects of clozapine leading to occurrence of OCS in a subgroup of patients is possible, and needs further evaluation by longitudinal follow-up studies.en_US
dc.identifier.doi10.1002/hup.2857en_US
dc.identifier.eissn1099-1077
dc.identifier.issn0885-6222
dc.identifier.urihttp://hdl.handle.net/11693/111291
dc.language.isoEnglishen_US
dc.publisherJohn Wiley and Sons, Ltden_US
dc.relation.isversionofhttps://www.doi.org/10.1002/hup.2857en_US
dc.source.titleHuman Psychopharmacology: Clinical and Experimentalen_US
dc.subjectClozapinen_US
dc.subjectDiffusion tensor imagingen_US
dc.subjectRactional anisotropyen_US
dc.subjectObsessive compulsive symptomen_US
dc.subjectSchizophreniaen_US
dc.titleA diffusion tensor imaging study in schizophrenia patients with clozapine induced obsessive compulsive symptomsen_US
dc.typeArticleen_US
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