Survey of factor V leiden and prothrombin gene mutations in systemic lupus erythematosus

Simple item page
dc.citation.epage261en_US
dc.citation.issueNumber4en_US
dc.citation.spage259en_US
dc.citation.volumeNumber20en_US
dc.contributor.authorTopaloglu, R.en_US
dc.contributor.authorAkıerli, C.en_US
dc.contributor.authorBakkaloglu, A.en_US
dc.contributor.authorAydıntug, O.en_US
dc.contributor.authorOzen, S.en_US
dc.contributor.authorBesbas, N.en_US
dc.contributor.authorOzcelik, T.en_US
dc.date.accessioned2019-02-05T13:49:31Z
dc.date.available2019-02-05T13:49:31Z
dc.date.issued2001en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractThe two most common hereditary risk factors for thrombosis are factor V Leiden mutation and a prothrombin gene mutation. There is indeed a thrombotic tendency in patients with systemic lupus erythematosis (SLE) and it is not always associated with antiphospholipid antibodies. We aimed to determine the relationship between both factor V Leiden and prothrombin gene mutations and SLE. Using polymerase chain reaction (PCR) the factor V Leiden and prothrombin gene mutations were evaluated in 55 patients (20 children and 35 adults) with SLE. Although seven patients were found to have factor V Leiden mutation in the heterozygous state, two had the heterozygous G→A (20210) prothrombin gene mutation. Although one had these two mutations concurrently, these two patients did not have thrombosis. The factor V Leiden mutation frequency (12.7%) was higher than that of our general population (7.1%). On the other hand, seven of the patients with SLE had a thrombotic event. Although of these seven, four (57%) had factor V Leiden mutation, three (43%) had no mutation. Of 48 patients with no thrombotic history, only three had the factor V mutation (6.25%). The prevalence of the factor V Leiden mutation in SLE patients with and without thrombosis was significantly different by Fisher’s exact test (p<0.05). The risk of venous thrombosis in patients with factor V Leiden increased threefold compared to that in those without factor V Leiden mutation (odds ratio 20.1; CI 2.99–133.6). Although factor V Leiden mutation seems to play a role in the development of venous thrombosis in SLE, the development of thrombosis in SLE is multifactorial.en_US
dc.identifier.doi10.1007/s100670170en_US
dc.identifier.eissn1434-9949
dc.identifier.issn0770-3198
dc.identifier.urihttp://hdl.handle.net/11693/48901
dc.language.isoEnglishen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofhttps://doi.org/10.1007/s100670170en_US
dc.source.titleClinical Rheumatologyen_US
dc.subjectFactor V leidenen_US
dc.subjectGene mutationen_US
dc.subjectProthrombinen_US
dc.subjectSLEen_US
dc.subjectSystemic lupus erythematosusen_US
dc.titleSurvey of factor V leiden and prothrombin gene mutations in systemic lupus erythematosusen_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Survey of factor V leiden and prothrombin gene mutations in systemic lupus erythematosus.pdf
Size:
60.79 KB
Format:
Adobe Portable Document Format
Description:
Full printable version
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Department of Molecular Biology and Genetics