Recent advances in microneedle-based sensors for sampling, diagnosis and monitoring of chronic diseases

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buir.contributor.authorErdem, Özgecan
buir.contributor.authorİsmail, Eş
buir.contributor.authorAkceoğlu, Garbis Atam
buir.contributor.authorİnci, Fatih
buir.contributor.orcidErdem, Özgecan|0000-0002-1284-6113
buir.contributor.orcidİsmail, Eş|0000-0002-7369-1039
buir.contributor.orcidAkceoğlu, Garbis Atam|0000-0002-8274-4569
buir.contributor.orcidİnci, Fatih|0000-0002-9918-5038
dc.citation.epage22en_US
dc.citation.issueNumber296en_US
dc.citation.spage1en_US
dc.citation.volumeNumber11en_US
dc.contributor.authorErdem, Özgecan
dc.contributor.authorİsmail, Eş
dc.contributor.authorSaylan, Y.
dc.contributor.authorAkceoğlu, Garbis Atam
dc.contributor.authorİnci, Fatih
dc.date.accessioned2022-02-10T12:11:20Z
dc.date.available2022-02-10T12:11:20Z
dc.date.issued2021-08-25
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.description.abstractChronic diseases (CDs) are noncommunicable illnesses with long-term symptoms accounting for ~70% of all deaths worldwide. For the diagnosis and prognosis of CDs, accurate biomarker detection is essential. Currently, the detection of CD-associated biomarkers is employed through complex platforms with certain limitations in their applicability and performance. There is hence unmet need to present innovative strategies that are applicable to the point-of-care (PoC) settings, and also, provide the precise detection of biomarkers. On the other hand, especially at PoC settings, microneedle (MN) technology, which comprises micron-size needles arranged on a miniature patch, has risen as a revolutionary approach in biosensing strategies, opening novel horizons to improve the existing PoC devices. Various MN-based platforms have been manufactured for distinctive purposes employing several techniques and materials. The development of MN-based biosensors for real-time monitoring of CD-associated biomarkers has garnered huge attention in recent years. Herein, we summarize basic concepts of MNs, including microfabrication techniques, design parameters, and their mechanism of action as a biosensing platform for CD diagnosis. Moreover, recent advances in the use of MNs for CD diagnosis are introduced and finally relevant clinical trials carried out using MNs as biosensing devices are highlighted. This review aims to address the potential use of MNs in CD diagnosis.en_US
dc.identifier.doi10.3390/bios11090296en_US
dc.identifier.issn2079-6374
dc.identifier.urihttp://hdl.handle.net/11693/77235
dc.language.isoEnglishen_US
dc.publisherMDPI AGen_US
dc.relation.isversionofhttps://doi.org/10.3390/bios11090296en_US
dc.source.titleBiosensorsen_US
dc.subjectChronic diseaseen_US
dc.subjectBiomarkersen_US
dc.subjectDetection methodsen_US
dc.subjectMicroneedlesen_US
dc.subjectBiosensoren_US
dc.titleRecent advances in microneedle-based sensors for sampling, diagnosis and monitoring of chronic diseasesen_US
dc.typeReviewen_US
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