Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population

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dc.citation.epage464en_US
dc.citation.issueNumber8en_US
dc.citation.spage459en_US
dc.citation.volumeNumber75en_US
dc.contributor.authorTörüner, G. A.en_US
dc.contributor.authorAkyerli, C.en_US
dc.contributor.authorUçar, A.en_US
dc.contributor.authorAki, T.en_US
dc.contributor.authorAtsu, N.en_US
dc.contributor.authorÖzen, H.en_US
dc.contributor.authorTez, M.en_US
dc.contributor.authorÇetinkaya, M.en_US
dc.contributor.authorÖzçelik, T.en_US
dc.date.accessioned2016-02-08T10:34:23Z
dc.date.available2016-02-08T10:34:23Z
dc.date.issued2001en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractWe investigated the effect of the GSTM1 and GSTT1 null genotypes, and GSTP1 313 A/G polymorphism on bladder cancer susceptibility in a case control study of 121 bladder cancer patients, and 121 age- and sex-matched controls of the Turkish population. The adjusted odds ratio for age, sex, and smoking status is 1.94 [95% confidence intervals (CI) 1.15-3.26] for the GSTM1 null genotype, and 1.75 (95% CI 1.03-2.99) for the GSTP1 313 A/G or G/G genotypes. GSTT1 was shown not to be associated with bladder cancer. Combination of the two high-risk genotypes, GSTM1 null and GSTP1 313 A/G or G/G, revealed that the risk increases to 3.91-fold (95% CI 1.88-8.13) compared with the combination of the low-risk genotypes of these loci. In individuals with the combined risk factors of cigarette smoking and the GSTM1 null genotype, the risk of bladder cancer is 2.81 times (95% CI 1.23-6.35) that of persons who both carry the GSTMl-present genotype and do not smoke. Similarly, the risk is 2.38-fold (95% CI 1.12-4.95) for the combined GSTP1 313 A/G and G/G genotypes and smoking. These findings support the role for the GSTM1 null and the GSTP1 313 AG or GG genotypes in the development of bladder cancer. Furthermore, gene-gene (GSTM1-GSTP1) and gene-environment (GSTMl-smoking, GSTP1-smoking) interactions increase this risk substantially.en_US
dc.identifier.doi10.1007/s002040100268en_US
dc.identifier.issn0340-5761
dc.identifier.urihttp://hdl.handle.net/11693/24789
dc.language.isoEnglishen_US
dc.publisherSpringeren_US
dc.relation.isversionofhttp://dx.doi.org/10.1007/s002040100268en_US
dc.source.titleArchives of Toxicologyen_US
dc.subjectBladder canceren_US
dc.subjectGene polymorphismen_US
dc.subjectGlutathione transferaseen_US
dc.subjectGlutathione transferaseen_US
dc.subjectGenetic polymorphismen_US
dc.subjectGenotypeen_US
dc.subjectMajor clinical studyen_US
dc.subjectPriority journalen_US
dc.subjectTurkey (republic)en_US
dc.subjectGenetic predisposition to diseaseen_US
dc.subjectGenotypeen_US
dc.subjectGlutathione S-Transferase pien_US
dc.subjectGlutathione transferaseen_US
dc.subjectIsoenzymesen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectPolymorphism, Geneticen_US
dc.subjectUrinary bladder neoplasmsen_US
dc.titlePolymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish populationen_US
dc.typeArticleen_US
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