High-resolution magic anglespinning ¹H nuclear magnetic resonance spectroscopy metabolomics of hyperfunctioning parathyroid glands

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dc.citation.epage394en_US
dc.citation.issueNumber2en_US
dc.citation.spage384en_US
dc.citation.volumeNumber160en_US
dc.contributor.authorBattini, S.en_US
dc.contributor.authorImperiale, A.en_US
dc.contributor.authorTaïeb, D.en_US
dc.contributor.authorElbayed, K.en_US
dc.contributor.authorCicek, A. E.en_US
dc.contributor.authorSebag, F.en_US
dc.contributor.authorBrunaud, L.en_US
dc.contributor.authorNamer, Izzie-Jacquesen_US
dc.date.accessioned2018-04-12T10:52:43Z
dc.date.available2018-04-12T10:52:43Z
dc.date.issued2016en_US
dc.departmentDepartment of Computer Engineeringen_US
dc.description.abstractBackground Primary hyperparathyroidism (PHPT) may be related to a single gland disease or multiglandular disease, which requires specific treatments. At present, an operation is the only curative treatment for PHPT. Currently, there are no biomarkers available to identify these 2 entities (single vs. multiple gland disease). The aims of the present study were to compare (1) the tissue metabolomics profiles between PHPT and renal hyperparathyroidism (secondary and tertiary) and (2) single gland disease with multiglandular disease in PHPT using metabolomics analysis. Methods The method used was 1H high-resolution magic angle spinning nuclear magnetic resonance spectroscopy. Forty-three samples from 32 patients suffering from hyperparathyroidism were included in this study. Results Significant differences in the metabolomics profile were assessed according to PHPT and renal hyperparathyroidism. A bicomponent orthogonal partial least square-discriminant analysis showed a clear distinction between PHPT and renal hyperparathyroidism (R2Y = 0.85, Q2 = 0.63). Interestingly, the model also distinguished single gland disease from multiglandular disease (R2Y = 0.96, Q2 = 0.55). A network analysis was also performed using the Algorithm to Determine Expected Metabolite Level Alterations Using Mutual Information (ADEMA). Single gland disease was accurately predicted by ADEMA and was associated with higher levels of phosphorylcholine, choline, glycerophosphocholine, fumarate, succinate, lactate, glucose, glutamine, and ascorbate compared with multiglandular disease. Conclusion This study shows for the first time that 1H high-resolution magic angle spinning nuclear magnetic resonance spectroscopy is a reliable and fast technique to distinguish single gland disease from multiglandular disease in patients with PHPT. The potential use of this method as an intraoperative tool requires specific further studies.en_US
dc.identifier.doi10.1016/j.surg.2016.03.002en_US
dc.identifier.issn0039-6060
dc.identifier.urihttp://hdl.handle.net/11693/36770
dc.language.isoEnglishen_US
dc.publisherMosby, Inc.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.surg.2016.03.002en_US
dc.source.titleSurgeryen_US
dc.subjectPrimaryen_US
dc.subjectAlanineen_US
dc.subjectArginineen_US
dc.subjectAscorbic aciden_US
dc.subjectBiological markeren_US
dc.subjectCholineen_US
dc.subjectCreatineen_US
dc.subjectFumaric aciden_US
dc.subjectGlucoseen_US
dc.subjectGlutamic aciden_US
dc.subjectGlutamineen_US
dc.subjectGlutathioneen_US
dc.subjectGlycerophosphorylcholineen_US
dc.subjectGlycogenen_US
dc.subjectInositolen_US
dc.subjectLactic aciden_US
dc.subjectLeucineen_US
dc.subjectLysineen_US
dc.subjectPhosphorylcholineen_US
dc.subjectSuccinic aciden_US
dc.subjectTaurineen_US
dc.subjectValineen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectAlgorithmen_US
dc.subjectClinical articleen_US
dc.subjectComparative studyen_US
dc.subjectDiagnostic accuracyen_US
dc.subjectDiscriminant analysisen_US
dc.subjectFemaleen_US
dc.subjectHigh resolution magic angle spinning proton nuclear magnetic resonanceen_US
dc.subjectHumanen_US
dc.subjectHuman tissueen_US
dc.subjectHyperparathyroidismen_US
dc.subjectMaleen_US
dc.subjectMetabolomicsen_US
dc.subjectMiddle ageden_US
dc.subjectMultiple parathyroid gland diseaseen_US
dc.subjectNuclear magnetic resonance spectrometeren_US
dc.subjectParathyroid diseaseen_US
dc.subjectPartial least squares regressionen_US
dc.subjectPrimary hyperparathyroidismen_US
dc.subjectPriority journalen_US
dc.subjectProton nuclear magnetic resonanceen_US
dc.subjectRenal osteodystrophyen_US
dc.subjectSingle parathyroid gland diseaseen_US
dc.subjectTissue levelen_US
dc.subjectHyperparathyroidismen_US
dc.subjectSecondaryen_US
dc.subjectMetabolismen_US
dc.subjectPredictive valueen_US
dc.subjectPeproducibilityen_US
dc.subjectRetrospective studyen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectHyperparathyroidismen_US
dc.subjectHyperparathyroidismen_US
dc.subjectMagnetic Resonance Spectroscopyen_US
dc.subjectMaleen_US
dc.subjectMetabolomicsen_US
dc.subjectMiddle Ageden_US
dc.subjectPredictive Value of Testsen_US
dc.subjectReproducibility of Resultsen_US
dc.subjectRetrospective Studiesen_US
dc.titleHigh-resolution magic anglespinning ¹H nuclear magnetic resonance spectroscopy metabolomics of hyperfunctioning parathyroid glandsen_US
dc.typeArticleen_US
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