Evaluation of C/EBP(formula) as a candidate tumor suppressor gene in hepatocellular carcinoma

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buir.advisorYakıcıer, M. Cengiz
dc.contributor.authorYuva, Yeliz
dc.date.accessioned2016-07-01T11:01:11Z
dc.date.available2016-07-01T11:01:11Z
dc.date.issued2004
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.descriptionCataloged from PDF version of article.en_US
dc.description.abstractHepatocellular carcinoma (HCC) is the fifth common type of cancer and third leading cause of cancer deaths in the world. HCC is a genetically heterogeneous disease and multiple pathways and molecules are identified to have role in development of HCC. However, the molecular mechanisms underlying hepatocarcinogenesis are still poorly understood. The transcription factor CCAAT/enhancer binding protein alpha (C/EBPα) is important in differentiation of granulocytes, adipocytes and hepatocytes and mutations in C/EBPα were described in acute myeloid leukemia. C/EBPα is strong inhibitor of cell growth in liver and mouse lacking C/EBPα shows increased proliferation and phenotype resembling HCC. To clarify the role of C/EBPα in hepatocarcinogenesis, we analyzed the genetic alterations of the C/EBPα in HCCs. We have screened C/EBPα mutations in HCC cell lines and tumors by use of sequencing and heteroduplex analysis approaches. In HCC cell lines and tumors, mutations and polymorphisms have been found. Thus, alterations of C/EBPα are involved in hepatocellular carcinoma although it is not frequent. Ours is the first report of C/EBPα alterations in HCC in our knowledge.en_US
dc.description.degreeM.S.en_US
dc.description.statementofresponsibilityYuva, Yelizen_US
dc.format.extentxii, 54 leaves, illustrationsen_US
dc.identifier.itemidBILKUTUPB037462
dc.identifier.urihttp://hdl.handle.net/11693/29542
dc.language.isoEnglishen_US
dc.publisherBilkent Universityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject.lccQZ202 .Y88 2004en_US
dc.subject.lcshOncogenes.en_US
dc.titleEvaluation of C/EBP(formula) as a candidate tumor suppressor gene in hepatocellular carcinomaen_US
dc.typeThesisen_US
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Dept. of Molecular Biology and Genetics - Master's degree