From your nose to your toes: a review of severe acute respiratory syndrome coronavirus 2 pandemic‒associated pernio

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buir.contributor.authorÖzçelik, Tayfun
buir.contributor.orcidÖzçelik, Tayfun|0000-0001-5937-1082
dc.citation.epage2796en_US
dc.citation.issueNumber12en_US
dc.citation.spage2791en_US
dc.citation.volumeNumber141en_US
dc.contributor.authorArkin, L. M.
dc.contributor.authorMoon, J. J.
dc.contributor.authorTran, J. M.
dc.contributor.authorAsgari, S.
dc.contributor.authorO'Farrelly, C.
dc.contributor.authorCasanova, J. -L.
dc.contributor.authorCowen, E. W.
dc.contributor.authorMays, J. W.
dc.contributor.authorSingh, A. M.
dc.contributor.authorDrolet, B. A.
dc.contributor.authorAiuti, A.
dc.contributor.authorBelot, A.
dc.contributor.authorBolze, A.
dc.contributor.authorBondarenko, A.
dc.contributor.authorSediva, A.
dc.contributor.authorShcherbina, A.
dc.contributor.authorPlanas, A. M.
dc.contributor.authorCondino-Neto, A.
dc.contributor.authorPujol, A.
dc.contributor.authorCatherine, B.
dc.contributor.authorFlores, C.
dc.contributor.authorRodríguez-Gallego, C.
dc.contributor.authorPrando, C.
dc.contributor.authorDalgard, C. L.
dc.contributor.authorRoger, C.
dc.contributor.authorMansouri, D.
dc.contributor.authorvan, de Beek, D.
dc.contributor.authorVinh, D. C.
dc.contributor.authorHsieh, E.
dc.contributor.authorAndreakos, E.
dc.contributor.authorHaerynck, F.
dc.contributor.authorUddin, F.
dc.contributor.authorCasari, G.
dc.contributor.authorNovelli, G.
dc.contributor.authorPesole, G.
dc.contributor.authorMeyts, I.
dc.contributor.authorTancevski, I.
dc.contributor.authorFellay, J.
dc.contributor.authorTur, J.
dc.contributor.authorKisand, K.
dc.contributor.authorOkamoto, K.
dc.contributor.authorMironska, K.
dc.contributor.authorAbel, L.
dc.contributor.authorRenia, L.
dc.contributor.authorNg, L. F. P.
dc.contributor.authorShahrooei, M.
dc.contributor.authorSoler-Palacín, P.
dc.contributor.authorBrodin, P.
dc.contributor.authorPan-Hammarström, Q.
dc.contributor.authorHalwani, R.
dc.contributor.authorPerez, de Diego, R.
dc.contributor.authorAl-Muhsen, S.
dc.contributor.authorEspinosa-Padilla, S.
dc.contributor.authorOkada, S.
dc.contributor.authorÖzçelik, Tayfun
dc.contributor.authorTayoun, A. A.
dc.contributor.authorKaramitros, T.
dc.contributor.authorMogensen, T. H.
dc.contributor.authorLau, Y. L.
dc.date.accessioned2022-04-27T11:21:46Z
dc.date.available2022-04-27T11:21:46Z
dc.date.issued2021en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractDespite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.en_US
dc.identifier.doi10.1016/j.jid.2021.05.024en_US
dc.identifier.eissn1523-1747
dc.identifier.issn0022-202X
dc.identifier.urihttp://hdl.handle.net/11693/78166
dc.language.isoEnglishen_US
dc.publisherElsevier Ltden_US
dc.relation.isversionofhttps://dx.doi.org/10.1016/j.jid.2021.05.024en_US
dc.source.titleJournal of Investigative Dermatologyen_US
dc.titleFrom your nose to your toes: a review of severe acute respiratory syndrome coronavirus 2 pandemic‒associated pernioen_US
dc.typeArticleen_US
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