Effects of caloric restriction on the antagonistic and integrative hallmarks of aging

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buir.contributor.authorErbaba, Begün
buir.contributor.authorArslan-Ergül, Ayca
buir.contributor.authorAdams, Michelle M.
dc.citation.epage101228-9en_US
dc.citation.spage101228-1en_US
dc.citation.volumeNumber66en_US
dc.contributor.authorErbaba, Begün
dc.contributor.authorArslan-Ergül, Ayça
dc.contributor.authorAdams, Michelle M.
dc.date.accessioned2021-03-30T13:42:17Z
dc.date.available2021-03-30T13:42:17Z
dc.date.issued2021
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.departmentDepartment of Psychologyen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.description.abstractAging is a significant risk factor for cognitive decline associated with neurodegenerative diseases, which makes understanding what promotes ‘healthy brain aging’ very important. Studies suggest that caloric restriction (CR) is a non-genetic intervention that reliably extends life- and healthspan. Here, we review the CR literature related to both the subject of aging and alterations in cell cycle machinery, especially surrounding the regulation of the E2F/DP1 complex, to elucidate the cellular protection mechanisms in the brain induced via dietary applications. The alterations extending lifespan via CR appear to exert their effects by promoting survival of individual cells, downregulating cell proliferation, and inducing stem cell quiescence, which results in keeping the stem cell reserve for extreme needs. This survival instinct of cells is believed to cause some molecular adaptations for their maintenance of the system. Avoiding energy waste of proliferation machinery promotes the long term survival of the individual cells and this is due to adaptations to the limited nutrient supply in the environment. Such a protective mechanism induced by diet could be promoted via the downregulation of crucial cell cycle-related transcription activators. This review article aims to bring attention to the importance of molecular adaptations induced by diet that promote healthy brain aging. It will provide insights into alternative targets for new treatments or neuroprotective approaches against neurodegenerative pathophysiologies.en_US
dc.identifier.doi10.1016/j.arr.2020.101228en_US
dc.identifier.issn1568-1637
dc.identifier.urihttp://hdl.handle.net/11693/76022
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.arr.2020.101228en_US
dc.source.titleAgeing Research Reviewsen_US
dc.subjectBrainen_US
dc.subjectAgingen_US
dc.subjectCalorie restrictionen_US
dc.subjectNeuroinflammationen_US
dc.subjectCell cycleen_US
dc.titleEffects of caloric restriction on the antagonistic and integrative hallmarks of agingen_US
dc.typeArticleen_US
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Department of Psychology
Aysel Sabuncu Brain Research Center (BAM)
Institute of Materials Science and Nanotechnology (UNAM)