Reconfigurable MRI technology for low-SAR imaging of deep brain stimulation at 3T: application in bilateral leads, fully-implanted systems, and surgically modified lead trajectories

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buir.contributor.authorKazemivalipour, Ehsan
buir.contributor.authorAtalar, Ergin
dc.citation.epage29en_US
dc.citation.spage18en_US
dc.citation.volumeNumber199en_US
dc.contributor.authorKazemivalipour, Ehsanen_US
dc.contributor.authorKeil, B.en_US
dc.contributor.authorVali, A.en_US
dc.contributor.authorRajan, S.en_US
dc.contributor.authorElahi, B.en_US
dc.contributor.authorAtalar, Erginen_US
dc.contributor.authorWald, L.en_US
dc.contributor.authorRosenow, J.en_US
dc.contributor.authorPilitsis, J.en_US
dc.contributor.authorGolestanirad, L.en_US
dc.date.accessioned2020-02-12T11:51:11Z
dc.date.available2020-02-12T11:51:11Z
dc.date.issued2019
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.description.abstractPatients with deep brain stimulation devices highly benefit from postoperative MRI exams, however MRI is not readily accessible to these patients due to safety risks associated with RF heating of the implants. Recently we introduced a patient-adjustable reconfigurable coil technology that substantially reduced local SAR at tips of single isolated DBS leads during MRI at 1.5 T in 9 realistic patient models. This contribution extends our work to higher fields by demonstrating the feasibility of scaling the technology to 3T and assessing its performance in patients with bilateral leads as well as fully implanted systems. We developed patient-derived models of bilateral DBS leads and fully implanted DBS systems from postoperative CT images of 13 patients and performed finite element simulations to calculate SAR amplification at electrode contacts during MRI with a reconfigurable rotating coil at 3T. Compared to a conventional quadrature body coil, the reconfigurable coil system reduced the SAR on average by 83% for unilateral leads and by 59% for bilateral leads. A simple surgical modification in trajectory of implanted leads was demonstrated to increase the SAR reduction efficiency of the rotating coil to >90% in a patient with a fully implanted bilateral DBS system. Thermal analysis of temperature-rise around electrode contacts during typical brain exams showed a 15-fold heating reduction using the rotating coil, generating <1C temperature rise during ∼4-min imaging with high-SAR sequences where a conventional CP coil generated >10C temperature rise in the tissue for the same flip angle.en_US
dc.embargo.release2020-10-01
dc.identifier.doi10.1016/j.neuroimage.2019.05.015en_US
dc.identifier.issn0031-3203
dc.identifier.urihttp://hdl.handle.net/11693/53311
dc.language.isoEnglishen_US
dc.publisherElsevieren_US
dc.relation.isversionofhttps://doi.org/10.1016/j.neuroimage.2019.05.015en_US
dc.source.titleNeuroImageen_US
dc.subjectDeep brain stimulation (DBS)en_US
dc.subjectIndividualized medicineIn-silico medicineen_US
dc.subjectFinite elementen_US
dc.subjectMagnetic resonance imaging (MRI)en_US
dc.subjectMRI safetyen_US
dc.subjectNeuromodulationen_US
dc.subjectNeurostimulationen_US
dc.subjectMedical implantsen_US
dc.subjectReconfigurable MRIen_US
dc.subjectSimulationsen_US
dc.subjectSpecific absorption rate (SAR)en_US
dc.subjectMRI coilsen_US
dc.titleReconfigurable MRI technology for low-SAR imaging of deep brain stimulation at 3T: application in bilateral leads, fully-implanted systems, and surgically modified lead trajectoriesen_US
dc.typeArticleen_US
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National Magnetic Resonance Research Center (UMRAM)