An integrated acoustic and dielectrophoretic particle manipulation in a microfluidic device for particle wash and separation fabricated by mechanical machining

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dc.citation.issueNumber1en_US
dc.citation.volumeNumber10en_US
dc.contributor.authorÇetin B.en_US
dc.contributor.authorÖzer, M. B.en_US
dc.contributor.authorÇağatay, E.en_US
dc.contributor.authorBüyükkoçak S.en_US
dc.date.accessioned2018-04-12T10:47:31Z
dc.date.available2018-04-12T10:47:31Z
dc.date.issued2016en_US
dc.departmentDepartment of Mechanical Engineeringen_US
dc.description.abstractIn this study, acoustophoresis and dielectrophoresis are utilized in an integrated manner to combine the two different operations on a single polydimethylsiloxane (PDMS) chip in sequential manner, namely, particle wash (buffer exchange) and particle separation. In the washing step, particles are washed with buffer solution with low conductivity for dielectrophoretic based separation to avoid the adverse effects of Joule heating. Acoustic waves generated by piezoelectric material are utilized for washing, which creates standing waves along the whole width of the channel. Coupled electro-mechanical acoustic 3D multi-physics analysis showed that the position and orientation of the piezoelectric actuators are critical for successful operation. A unique mold is designed for the precise alignment of the piezoelectric materials and 3D side-wall electrodes for a highly reproducible fabrication. To achieve the throughput matching of acoustophoresis and dielectrophoresis in the integration, 3D side-wall electrodes are used. The integrated device is fabricated by PDMS molding. The mold of the integrated device is fabricated using high-precision mechanical machining. With a unique mold design, the placements of the two piezoelectric materials and the 3D sidewall electrodes are accomplished during the molding process. It is shown that the proposed device can handle the wash and dielectrophoretic separation successfully. © 2016 AIP Publishing LLC.en_US
dc.identifier.doi10.1063/1.4940431en_US
dc.identifier.issn1932-1058
dc.identifier.urihttp://hdl.handle.net/11693/36661
dc.language.isoEnglishen_US
dc.publisherAmerican Institute of Physics Inc.en_US
dc.relation.isversionofhttp://dx.doi.org/10.1063/1.4940431en_US
dc.source.titleBiomicrofluidicsen_US
dc.subjectDielectric devicesen_US
dc.subjectElectrodesen_US
dc.subjectElectrophoresisen_US
dc.subjectFabricationen_US
dc.subjectMechanical actuatorsen_US
dc.subjectMicrochannelsen_US
dc.subjectMoldingen_US
dc.subjectMoldsen_US
dc.subjectPiezoelectric materialsen_US
dc.subjectPiezoelectricityen_US
dc.subjectPolydimethylsiloxaneen_US
dc.subjectSeparationen_US
dc.subjectSiliconesen_US
dc.subjectWashingen_US
dc.titleAn integrated acoustic and dielectrophoretic particle manipulation in a microfluidic device for particle wash and separation fabricated by mechanical machiningen_US
dc.typeArticleen_US
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