Discovering modulators of gene expression
Date
2010-09-01
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Source Title
Nucleic Acids Research
Print ISSN
0305-1048
Electronic ISSN
1362-4962
Publisher
Oxford University Press
Volume
38
Issue
17
Pages
5648 - 5656
Language
English
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Abstract
Proteins that modulate the activity of transcription factors, often called modulators, play a critical role in creating tissue- and context-specific gene expression responses to the signals cells receive. GEM (Gene Expression Modulation) is a probabilistic framework that predicts modulators, their affected targets and mode of action by combining gene expression profiles, protein-protein interactions and transcription factor-target relationships. Using GEM, we correctly predicted a significant number of androgen receptor modulators and observed that most modulators can both act as co-activators and co-repressors for different target genes. © The Author(s) 2010. Published by Oxford University Press.
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Keywords
Androgen receptor , Transcription factor , Gene activation , Gene expression profiling , Gene expression regulation , Gene repression , Gene targeting , Priority journal , Probability , Protein function , Statistical analysis , Biological model , Evaluation study , Genetic transcription , Metabolism , Protein analysis