Prognostic value of p53 gene mutations in a large series of node-negative breast cancer patients

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dc.citation.epage1455en_US
dc.citation.issueNumber7en_US
dc.citation.spage1451en_US
dc.citation.volumeNumber58en_US
dc.contributor.authorFalette, N.en_US
dc.contributor.authorPaperin, M. P.en_US
dc.contributor.authorTreilleux, I.en_US
dc.contributor.authorGratadour, A. C.en_US
dc.contributor.authorPeloux, N.en_US
dc.contributor.authorMignotte, H.en_US
dc.contributor.authorTooke, N.en_US
dc.contributor.authorLöfman, E.en_US
dc.contributor.authorInganäs, M.en_US
dc.contributor.authorBremond, A.en_US
dc.contributor.authorOzturk, M.en_US
dc.contributor.authorPuisieux, A.en_US
dc.date.accessioned2016-02-08T10:45:16Z
dc.date.available2016-02-08T10:45:16Z
dc.date.issued1998en_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.description.abstractThe most important subgroup of breast cancer patients for which reliable prognostic factors are needed are women without axillary lymph node involvement. Although overall, these patients have a good prognosis, it is known that 20-30% will experience a recurrence of the disease. To determine the prognostic significance of P53 tumor suppressor gene mutation, specimens from 113 primary breast cancers were evaluated for the presence of P53 alterations, as detected by cDNA sequencing of the entire coding sequence of the gene. The median follow-up for patients was 105 months. P53 gene mutation was an independent prognostic marker of early relapse and death. Our results suggest that P53 gene mutations could be an important factor to identify node-negative patients who have a poor prognosis in the absence of adjuvant therapy. Prospective studies should be designed to determine which therapy should be performed in this subgroup of patients.en_US
dc.identifier.issn0008-5472
dc.identifier.urihttp://hdl.handle.net/11693/25472
dc.language.isoEnglishen_US
dc.source.titleCancer Researchen_US
dc.subjectProtein p53en_US
dc.subjectBreast canceren_US
dc.subjectCancer stagingen_US
dc.subjectGene mutationen_US
dc.subjectMajor clinical studyen_US
dc.titlePrognostic value of p53 gene mutations in a large series of node-negative breast cancer patientsen_US
dc.typeArticleen_US
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