Structural imaging of the brain reveals decreased total brain and total gray matter volumes in obese but not in lean women with polycystic ovary syndrome compared to body mass index-matched counterparts

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dc.citation.epage523en_US
dc.citation.issueNumber7en_US
dc.citation.spage519en_US
dc.citation.volumeNumber33en_US
dc.contributor.authorSaydam, B. O.en_US
dc.contributor.authorHas, A. C.en_US
dc.contributor.authorBozdag, G.en_US
dc.contributor.authorOguz, K. K.en_US
dc.contributor.authorYildiz, B. O.en_US
dc.date.accessioned2018-04-12T11:05:46Z
dc.date.available2018-04-12T11:05:46Z
dc.date.issued2017en_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.description.abstractPurpose: To detect differences in global brain volumes and identify relations between brain volume and appetite-related hormones in women with polycystic ovary syndrome (PCOS) compared to body mass index-matched controls. Methods: Forty subjects participated in this study. Cranial magnetic resonance imaging and measurements of fasting ghrelin, leptin and glucagon-like peptide 1 (GLP-1), as well as GLP-1 levels during mixed-meal tolerance test (MTT), were performed. Results: Total brain volume and total gray matter volume (GMV) were decreased in obese PCOS compared to obese controls (p < 0.05 for both) whereas lean PCOS and controls did not show a significant difference. Secondary analyses of regional brain volumes showed decreases in GMV of the caudate nucleus, ventral diencephalon and hippocampus in obese PCOS compared to obese controls (p < 0.05 for all), whereas lean patients with PCOS had lower GMV in the amygdala than lean controls (p < 0.05). No significant relations were detected between structural differences and measured hormone levels at baseline or during MTT. Conclusion: This study, investigating structural brain alterations in PCOS, suggests volumetric reductions in global brain areas in obese women with PCOS. Functional studies with larger sample size are needed to determine physiopathological roles of these changes and potential effects of long-term medical management on brain structure of PCOS. © 2017 Informa UK Limited, trading as Taylor & Francis Group.en_US
dc.identifier.doi10.1080/09513590.2017.1295440en_US
dc.identifier.issn0951-3590
dc.identifier.urihttp://hdl.handle.net/11693/37201
dc.language.isoEnglishen_US
dc.publisherTaylor and Francis Ltden_US
dc.relation.isversionofhttp://dx.doi.org/10.1080/09513590.2017.1295440en_US
dc.source.titleGynecological Endocrinologyen_US
dc.subjectAppetiteen_US
dc.subjectBrain imagingen_US
dc.subjectGhrelinen_US
dc.subjectGlucagon-like peptide-1en_US
dc.subjectObesityen_US
dc.subjectPolycystic ovary syndromeen_US
dc.titleStructural imaging of the brain reveals decreased total brain and total gray matter volumes in obese but not in lean women with polycystic ovary syndrome compared to body mass index-matched counterpartsen_US
dc.typeArticleen_US
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