This cluster-randomized pre-post comparison study examined the effects of using Sesame Workshop's Little Children, Big Challenges: General Resilience (LCBC) digital media toolkit in preschool classrooms over a 12-week period. Participants included 157 preschool teachers and 766 preschool children from 159 preschool classrooms in 38 Head Start centers, 7 Military Child Development Centers, 2 community-based preschool agencies, and a public school district. Children's social-emotional skills, behaviors, and relationship qualities were measured using a combination of direct testing of children and teacher behavioral ratings. Hierarchical linear modeling accounted for classroom-level nested data and the results indicated that LCBC increased emotion vocabulary, attachment, initiative, self-control, emotion regulation, and adaptability. The LCBC intervention also significantly reduced teacher conflict, attention problems, and emotion control problems. Additionally, the teacher survey indicated that the intervention was appealing to teachers and students. Reasons for nonsignificant effects on teacher closeness, social problem solving, and social skills are discussed.