• About
  • Policies
  • What is open access
  • Library
  • Contact
Advanced search
      View Item 
      •   BUIR Home
      • Scholarly Publications
      • National Magnetic Resonance Research Center (UMRAM)
      • View Item
      •   BUIR Home
      • Scholarly Publications
      • National Magnetic Resonance Research Center (UMRAM)
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Cortical connectivity in the face of congenital structural changes—A case of homozygous LAMC3 mutation

      Thumbnail
      View / Download
      4.5 Mb
      Author(s)
      Demirayak, P.
      Oğuz, Kader Karlı
      Üstün, Fatma Seyhun
      Ürgen, Buse Merve
      Topaç, Yasemin
      Gilani, İrtiza
      Kansu, T.
      Saygı, S.
      Özçelik, Tayfun
      Boyacı, Hüseyin
      Doerschner, Katja
      Date
      2021-08
      Source Title
      Brain and Behavior
      Print ISSN
      2162-3279
      Publisher
      John Wiley & Sons Ltd.
      Volume
      11
      Issue
      8
      Pages
      1 - 18
      Language
      English
      Type
      Article
      Item Usage Stats
      43
      views
      58
      downloads
      Abstract
      The homozygous LAMC3 gene mutation is associated with severe bilateral smoothening and thickening of the lateral occipital cortex . Despite this and further significant changes in gray matter structure, a patient harboring this mutation exhibited a range of remarkably intact perceptual abilities . One possible explanation of this perceptual sparing could be that the white matter structural integrity and functional connectivity in relevant pathways remained intact. To test this idea, we used diffusion tensor and functional magnetic resonance imaging to investigate functional connectivity in resting-state networks in major structural pathways involved in object perception and visual attention and corresponding microstructural integrity in a patient with homozygous LAMC3 mutation and sex, age, education, and socioeconomically matched healthy control group. White matter microstructural integrity results indicated widespread disruptions in both intra- and interhemispheric structural connections except inferior longitudinal fasciculus. With a few exceptions, the functional connectivity between the patient's adjacent gray matter regions of major white matter tracts of interest was conserved. In addition, functional localizers for face, object, and place areas showed similar results with a representative control, providing an explanation for the patient's intact face, place, and object recognition abilities. To generalize this finding, we also compared functional connectivity between early visual areas and face, place, and object category-selective areas, and we found that the functional connectivity of the patient was not different from the control group. Overall, our results provided complementary information about the effects of LAMC3 gene mutation on the human brain including intact temporo-occipital structural and functional connectivity that are compatible with preserved perceptual abilities.
      Keywords
      Diffusion tensor imaging
      Functional connectivity
      LAMC3
      Probabilistic tracktography
      Resting
      Permalink
      http://hdl.handle.net/11693/77462
      Published Version (Please cite this version)
      https://doi.org/10.1002/brb3.2241
      Collections
      • Department of Molecular Biology and Genetics 512
      • Department of Psychology 216
      • National Magnetic Resonance Research Center (UMRAM) 250
      Show full item record

      Browse

      All of BUIRCommunities & CollectionsTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsCoursesThis CollectionTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsCourses

      My Account

      Login

      Statistics

      View Usage StatisticsView Google Analytics Statistics

      Bilkent University

      If you have trouble accessing this page and need to request an alternate format, contact the site administrator. Phone: (312) 290 2976
      © Bilkent University - Library IT

      Contact Us | Send Feedback | Off-Campus Access | Admin | Privacy