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      • Department of Molecular Biology and Genetics
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      CHRNA5 belongs to the secondary estrogen signaling network exhibiting prognostic significance in breast cancer

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      Author(s)
      Shehwana, Huma
      Keskus, Ayse Gokce
      Ozdemir, E. Sila
      Acikgöz, Azer Aylin
      Biyik-Sit, Rumeysa
      Cagnan, I.
      Gunes, Damla
      Jahja, Ermira
      Cingir-Koker, Sahika
      Olmezer, Gizem
      Sucularli, Ceren
      Konu, Ozlen
      Date
      2021-04
      Source Title
      Cellular Oncology
      Electronic ISSN
      1875-8606
      Publisher
      Springer
      Volume
      44
      Pages
      453 - 472
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Cholinergic signals can be important modulators of cellular signaling in cancer. We recently have shown that knockdown of nicotinic acetylcholine receptor subunit alpha 5, CHRNA5, diminishes the proliferative potential of breast cancer cells. However, modulation of CHRNA5 expression in the context of estrogen signaling and its prognostic implications in breast cancer remained unexplored.
      Keywords
      Breast cancer
      CHRNA5
      Meta-analysis
      Co-expression network
      Estrogen receptor targets
      Estrogen treatment
      Prognosis
      Permalink
      http://hdl.handle.net/11693/77429
      Published Version (Please cite this version)
      https://doi.org/10.1007/s13402-020-00581-x
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 228
      • Department of Molecular Biology and Genetics 512
      • Institute of Materials Science and Nanotechnology (UNAM) 2098
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