Show simple item record

dc.contributor.authorde Zwarte, S. M. C.
dc.contributor.authorBrouwer, R.
dc.contributor.authorAgartz, I.
dc.contributor.authorAlda, M.
dc.contributor.authorAlonso-Lana, S.
dc.contributor.authorBearden, C.
dc.contributor.authorBertolino, A.
dc.contributor.authorBonvino, A.
dc.contributor.authorBramon, E.
dc.contributor.authorBuimer, E.
dc.contributor.authorCahn, W.
dc.contributor.authorCanales-Rodríguez, E.
dc.contributor.authorCannon, D. M.
dc.contributor.authorCannon, T. D.
dc.contributor.authorCaseras, X.
dc.contributor.authorCastro-Fornieles, J.
dc.contributor.authorChen, Q.
dc.contributor.authorChung, Y.
dc.contributor.authorDe la Serna, E.
dc.contributor.authordel Mar Bonnin, C.
dc.contributor.authorDemro, C.
dc.contributor.authorDi Giorgio, A.
dc.contributor.authorDoucet, G.
dc.contributor.authorEker, M.
dc.contributor.authorErk, S.
dc.contributor.authorFatjó-Vilas, M.
dc.contributor.authorFears, S.
dc.contributor.authorFoley, S.
dc.contributor.authorFrangou, S.
dc.contributor.authorFullerton, J.
dc.contributor.authorGlahn, D.
dc.contributor.authorGoghari, V.
dc.contributor.authorGoikolea, J.
dc.contributor.authorGoldman, A.
dc.contributor.authorGonul, A.
dc.contributor.authorGruber, O.
dc.contributor.authorHajek, T.
dc.contributor.authorHawkins, E.
dc.contributor.authorHeinz, A.
dc.contributor.authorOngun, C.
dc.contributor.authorHillegers, M.
dc.contributor.authorHouenou, J.
dc.contributor.authorPol, H.
dc.contributor.authorHultman, C.
dc.contributor.authorIngvar, M.
dc.contributor.authorJohansson, V.
dc.contributor.authorJönsson, E.
dc.contributor.authorKane, F.
dc.contributor.authorKempton, M.
dc.contributor.authorKoenis, M.
dc.contributor.authorKopecek, M.
dc.contributor.authorKrämer, B.
dc.contributor.authorLawrie, S.
dc.contributor.authorLenroot, R.
dc.contributor.authorMarcelis, M.
dc.contributor.authorMattay, V.
dc.contributor.authorMcDonald, C.
dc.contributor.authorMeyer-Lindenberg, A.
dc.contributor.authorMichielse, S.
dc.contributor.authorMitchell, P.
dc.contributor.authorMoreno, D.
dc.contributor.authorMurray, R.
dc.contributor.authorMwangi, B.
dc.contributor.authorNabulsi, L.
dc.contributor.authorNewport, J.
dc.contributor.authorOlman, C.
dc.contributor.authorvan Os, J.
dc.contributor.authorOvers, B.
dc.contributor.authorOzerdem, A.
dc.contributor.authorPergola, G.
dc.contributor.authorPicchioni, M.
dc.contributor.authorPiguet, C.
dc.contributor.authorPomarol-Clotet, E.
dc.contributor.authorRadua, J.
dc.contributor.authorRamsay, I.
dc.contributor.authorRichter, A.
dc.contributor.authorRoberts, G.
dc.contributor.authorSalvador, R.
dc.contributor.authorSaricicek-Aydogan, A.
dc.contributor.authorSarró, S.
dc.contributor.authorSchofield, P.
dc.contributor.authorSimsek, E.
dc.contributor.authorSimsek, F.
dc.contributor.authorSoares, J.
dc.contributor.authorSponheim, S.
dc.contributor.authorSugranyes, G.
dc.contributor.authorToulopoulou, Timothea
dc.contributor.authorTronchin, G.
dc.contributor.authorVieta, E.
dc.contributor.authorWalter, H.
dc.contributor.authorWeinberger, D.
dc.contributor.authorWhalley, H.
dc.contributor.authorWu, M. -J.
dc.contributor.authorYalin, N.
dc.contributor.authorAndreassen, O.
dc.contributor.authorChing, C.
dc.contributor.authorThomopoulos, S.
dc.contributor.authorvan Erp, T.
dc.contributor.authorJahanshad, N.
dc.contributor.authorThompson, P.
dc.contributor.authorKahn, R.
dc.contributor.authorvan Haren, N.
dc.date.accessioned2021-03-09T07:19:03Z
dc.date.available2021-03-09T07:19:03Z
dc.date.issued2020
dc.identifier.issn1065-9471
dc.identifier.urihttp://hdl.handle.net/11693/75901
dc.description.abstractFirst‐degree relatives of patients diagnosed with schizophrenia (SZ‐FDRs) show similar patterns of brain abnormalities and cognitive alterations to patients, albeit with smaller effect sizes. First‐degree relatives of patients diagnosed with bipolar disorder (BD‐FDRs) show divergent patterns; on average, intracranial volume is larger compared to controls, and findings on cognitive alterations in BD‐FDRs are inconsistent. Here, we performed a meta‐analysis of global and regional brain measures (cortical and subcortical), current IQ, and educational attainment in 5,795 individuals (1,103 SZ‐FDRs, 867 BD‐FDRs, 2,190 controls, 942 schizophrenia patients, 693 bipolar patients) from 36 schizophrenia and/or bipolar disorder family cohorts, with standardized methods. Compared to controls, SZ‐FDRs showed a pattern of widespread thinner cortex, while BD‐FDRs had widespread larger cortical surface area. IQ was lower in SZ‐FDRs (d = −0.42, p = 3 × 10−5), with weak evidence of IQ reductions among BD‐FDRs (d = −0.23, p = .045). Both relative groups had similar educational attainment compared to controls. When adjusting for IQ or educational attainment, the group‐effects on brain measures changed, albeit modestly. Changes were in the expected direction, with less pronounced brain abnormalities in SZ‐FDRs and more pronounced effects in BD‐FDRs. To conclude, SZ‐FDRs and BD‐FDRs show a differential pattern of structural brain abnormalities. In contrast, both had lower IQ scores and similar school achievements compared to controls. Given that brain differences between SZ‐FDRs and BD‐FDRs remain after adjusting for IQ or educational attainment, we suggest that differential brain developmental processes underlying predisposition for schizophrenia or bipolar disorder are likely independent of general cognitive impairment.en_US
dc.description.sponsorshipAustralian National Health and Medical Research Council Grants. Grant Numbers: 1037196, 1063960, 1066177, 510135, 1176716 Canadian Institutes of Health Research. Grant Numbers: 103703, 106469, 142255 Departament de Salut de la Generalitat de Catalunya. Grant Number: SLT002/16/00331 Deutsche Forschungsgemeinschaft. Grant Number: 1617 Development Service Merit Review Award. Grant Number: I01CX000227 Dokuz Eylul University Department of Scientific Research Projects Funding. Grant Number: 2012.KB.SAG.062 e:Med program. Grant Numbers: O1ZX1314B, O1ZX1314G Ege University School of Medicine Research Foundation. Grant Number: 2009‐D‐00017 Fundacio Marato TV3. Grant Number: 091630 Geestkracht program of the Netherlands Organisation for Health Research and Development. Grant Number: 10‐000‐1002 Generalitat de Catalunya. Grant Number: 2017SGR01271 German Federal Ministry for Education and Research Medical Research Council. Grant Number: G0901310 Ministerstvo Zdravotnictví Ceské Republiky. Grant Numbers: NR8786, NT13891 National Alliance for Research on Schizophrenia and Depression. Grant Numbers: 17319, 20244, 26731 Swiss National Centre of Competence in Research Robotics. Grant Number: 51NF40‐185897 National Institute of Mental Health. Grant Numbers: 1S10OD017974‐01, P30 NS076408, R01 MH052857, R01 MH080912, R01 MH113619, U01 MH108150, R01 MH085667 National Institute on Aging. Grant Number: T32AG058507 National Institutes of Health. Grant Numbers: P41 EB015922, R01 MH111671, R01 MH116147, R01 MH117601, R01MH121246, R03 MH105808, U54EB020403 Research Council of Norway. Grant Number: 223273 Spanish Ministry of Economy and Competitiveness/Instituto de Salud Carlos III. Grant Numbers: CPII19/00009, PI070066, PI1100683, PI1500467, PI18/00976 Stanley Medical Research Institute Swedish Research Council. Grant Numbers: K2007‐62X‐15077‐04‐1, K2008‐62P‐20597‐01‐3, K2010‐62X‐15078‐07‐2, K2012‐61X‐15078‐09‐3 Swiss National Science Foundation. Grant Number: 32003B_156914 VIDI. Grant Numbers: 452‐11‐014, 917‐46‐370 Wellcome Trust. Grant Numbers: 085475/B/08/Z, 085475/Z/08/Z Wellcome Trust Research Training Fellowship. Grant Number: 064971 ZonMw. Grant Number: 908‐02‐123en_US
dc.language.isoEnglishen_US
dc.source.titleHuman Brain Mappingen_US
dc.relation.isversionofhttps://dx.doi.org/10.1002/hbm.25206en_US
dc.subjectBipolar disorderen_US
dc.subjectEducationen_US
dc.subjectIntelligenceen_US
dc.subjectNeuroimagingen_US
dc.subjectRelativesen_US
dc.subjectSchizophreniaen_US
dc.titleIntelligence, educational attainment, and brain structure in those at familial high‐risk for schizophrenia or bipolar disorderen_US
dc.typeArticleen_US
dc.departmentDepartment of Psychologyen_US
dc.identifier.doi10.1002/hbm.25206en_US
dc.publisherWileyen_US
dc.contributor.bilkentauthorToulopoulou, Timothea


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record