• About
  • Policies
  • What is open access
  • Library
  • Contact
Advanced search
      View Item 
      •   BUIR Home
      • Scholarly Publications
      • Aysel Sabuncu Brain Research Center (BAM)
      • View Item
      •   BUIR Home
      • Scholarly Publications
      • Aysel Sabuncu Brain Research Center (BAM)
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Zebrafish brain RNA sequencing reveals that cell adhesion molecules are critical in brain aging

      Thumbnail
      Embargo Lift Date: 2021-10-01
      View / Download
      2.0 Mb
      Author(s)
      Erbaba, Begün
      Burhan, Özge Pelin
      Şerifoğlu, Naz
      Muratoğlu, B.
      Kahveci, Fatma
      Adams, Michelle M.
      Arslan-Ergül, A.
      Date
      2020
      Source Title
      Neurobiology of Aging
      Print ISSN
      0197-4580
      Publisher
      Elsevier
      Volume
      94
      Pages
      164 - 175
      Language
      English
      Type
      Article
      Item Usage Stats
      97
      views
      55
      downloads
      Abstract
      Brain aging is a complex process, which involves multiple pathways including various components from cellular to molecular. This study aimed to investigate the gene expression changes in zebrafish brains through young-adult to adult, and adult to old age. RNA sequencing was performed on isolated neuronal cells from zebrafish brains. The cells were enriched in progenitor cell markers, which are known to diminish throughout the aging process. We found 176 statistically significant, differentially expressed genes among the groups, and identified a group of genes based on gene ontology descriptions, which were classified as cell adhesion molecules. The relevance of these genes was further tested in another set of zebrafish brains, human healthy, and Alzheimer’s disease brain samples, as well as in Allen Brain Atlas data. We observed that the expression change of 2 genes, GJC2 and ALCAM, during the aging process was consistent in all experimental sets. Our findings provide a new set of markers for healthy brain aging and suggest new targets for therapeutic approaches to neurodegenerative diseases.
      Keywords
      Zebrafish
      Brain aging
      Cell adhesion molecules
      RNA sequencing
      Permalink
      http://hdl.handle.net/11693/75823
      Published Version (Please cite this version)
      https://dx.doi.org/10.1016/j.neurobiolaging.2020.04.017
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 228
      • Department of Computer Engineering 1510
      • Department of Molecular Biology and Genetics 512
      • Department of Psychology 216
      • Institute of Materials Science and Nanotechnology (UNAM) 2098
      • Nanotechnology Research Center (NANOTAM) 1125
      • National Magnetic Resonance Research Center (UMRAM) 250
      Show full item record

      Browse

      All of BUIRCommunities & CollectionsTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsCoursesThis CollectionTitlesAuthorsAdvisorsBy Issue DateKeywordsTypeDepartmentsCourses

      My Account

      Login

      Statistics

      View Usage StatisticsView Google Analytics Statistics

      Bilkent University

      If you have trouble accessing this page and need to request an alternate format, contact the site administrator. Phone: (312) 290 2976
      © Bilkent University - Library IT

      Contact Us | Send Feedback | Off-Campus Access | Admin | Privacy