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dc.contributor.authorTürk, C.
dc.contributor.authorTürk, S.
dc.contributor.authorTemirci, Elif Sena
dc.contributor.authorMalkan, Ü. Y.
dc.contributor.authorHaznedaroğlu, İ. C.
dc.date.accessioned2021-02-27T10:18:48Z
dc.date.available2021-02-27T10:18:48Z
dc.date.issued2020
dc.identifier.issn1470-3203
dc.identifier.urihttp://hdl.handle.net/11693/75620
dc.description.abstractIntroduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently identified coronavirus family member that triggers a respiratory disease similar to severe acute respiratory syndrome coronavirus (SARS-CoV). SARS-CoV and SARS-CoV-2 are very similar to each other in many respects, such as structure, genetics, and pathobiology. We hypothesized that coronaviruses could affect pulmonary tissues via integration with the critical immune genes after their interaction with renin–angiotensin system (RAS) elements. The aim of the present bioinformatics study was to assess expression changes of the RAS and non-RAS genes, particularly immune response genes, in the lung epithelial cells after infection with SARS-CoV. Methods: Linear regression, hierarchical clustering, pathway analysis, and network analysis were performed using the E-GEOD-17400 data set. Results: The whole-genome expression data of the lung epithelial cells infected with SARS-CoV for 12, 24, and 48 hours were analyzed, and a total of 15 RAS family and 29 immune genes were found to be highly correlated with the exposure time to the virus in the studied groups. Conclusion: RAS genes are important at the initiation of the infections caused by coronavirus family members and may have a strong relationship with the exchange of immune genes in due course following the infection.en_US
dc.language.isoEnglishen_US
dc.source.titleJournal of the Renin-Angiotensin-Aldosterone Systemen_US
dc.relation.isversionofhttps://doi.org/10.1177/1470320320928872en_US
dc.subjectRASen_US
dc.subjectANPEPen_US
dc.subjectACE2en_US
dc.subjectEGFRen_US
dc.subjectIGF2Ren_US
dc.subjectSARS-CoVen_US
dc.subjectSARS-CoV-2en_US
dc.subjectImmune system genesen_US
dc.titleIn vitro analysis of the renin–angiotensin system and inflammatory gene transcripts in human bronchial epithelial cells after infection with severe acute respiratory syndrome coronavirusen_US
dc.typeArticleen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.citation.spage1en_US
dc.citation.epage9en_US
dc.citation.volumeNumber21en_US
dc.citation.issueNumber2en_US
dc.identifier.doi10.1177/1470320320928872en_US
dc.publisherSAGEen_US
dc.contributor.bilkentauthorTemirci, Elif Sena


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