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dc.contributor.authorAyan, Seylan
dc.contributor.authorGünaydın, G.
dc.contributor.authorYeşilgül-Mehmetcik, Nisa
dc.contributor.authorGedik, M. E.
dc.contributor.authorSeven, Özlem
dc.contributor.authorAkkaya, Engin U.
dc.date.accessioned2021-02-26T20:11:02Z
dc.date.available2021-02-26T20:11:02Z
dc.date.issued2020-11
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/11693/75617
dc.description.abstractWe propose to overcome oxygen deficiency and light attenuation problems in photodynamic therapy (PDT), by separating photoexcitation and singlet oxygen delivery of the PDT process into two distinct operations to be carried out sequentially, at different locations. We now demonstrate the viability of this approach, using 2-pyridone derivative which yields a relatively stable endoperoxide. The initial storage endoperoxide obtained is transformed enzymatically into a more labile compound when placed in hypoxic cell cultures, and releases singlet oxygen significantly faster. The potential of this approach in advancing PDT beyond its current limits is exciting.en_US
dc.language.isoEnglishen_US
dc.source.titleChemical Communicationsen_US
dc.relation.isversionofhttps://dx.doi.org/10.1039/d0cc06031cen_US
dc.titleProof-of-principle for two-stage photodynamic therapy: Hypoxia triggered release of singlet oxygenen_US
dc.typeArticleen_US
dc.departmentDepartment of Chemistryen_US
dc.citation.spage14793en_US
dc.citation.epage14796en_US
dc.citation.volumeNumber56en_US
dc.citation.issueNumber94en_US
dc.identifier.doi10.1039/d0cc06031cen_US
dc.publisherRoyal Society of Chemistryen_US
dc.contributor.bilkentauthorAyan, Seylan
dc.contributor.bilkentauthorYeşilgül-Mehmetcik, Nisa
dc.contributor.bilkentauthorAkkaya, Engin U.


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