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dc.contributor.authorTarun, O. B.
dc.contributor.authorOkur, Halil I.
dc.contributor.authorRangaman, P.
dc.contributor.authorRoke, S.
dc.date.accessioned2021-02-25T07:57:43Z
dc.date.available2021-02-25T07:57:43Z
dc.date.issued2020
dc.identifier.issn2399-3669
dc.identifier.urihttp://hdl.handle.net/11693/75581
dc.description.abstractCell membranes are composed of a hydrated lipid bilayer that is molecularly complex and diverse, and the link between molecular hydration structure and membrane macroscopic properties is not well understood, due to a lack of technology that can probe and relate molecular level hydration information to micro- and macroscopic properties. Here, we demonstrate a direct link between lipid hydration structure and macroscopic dynamic curvature fluctuations. Using high-throughput wide-field second harmonic (SH) microscopy, we observe the formation of transient domains of ordered water at the interface of freestanding lipid membranes. These domains are induced by the binding of divalent ions and their structure is ion specific. Using nonlinear optical theory, we convert the spatiotemporal SH intensity into maps of membrane potential, surface charge density, and binding free energy. Using an electromechanical theory of membrane bending, we show that transient electric field gradients across the membrane induce spatiotemporal membrane curvature fluctuations.en_US
dc.language.isoEnglishen_US
dc.source.titleCommunications Chemistryen_US
dc.relation.isversionofhttps://dx.doi.org/10.1038/s42004-020-0263-8en_US
dc.titleTransient domains of ordered water induced by divalent ions lead to lipid membrane curvature fluctuationsen_US
dc.typeArticleen_US
dc.citation.volumeNumber3en_US
dc.citation.issueNumber1en_US
dc.identifier.doi10.1038/s42004-020-0263-8en_US
dc.publisherNature Researchen_US
dc.contributor.bilkentauthorOkur, Halil I.


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