Dynamic resource scheduling of biomanufacturing projects
Author
Limon, Yasemin
Date
2020-05-02Source Title
Computers and Industrial Engineering
Print ISSN
0360-8352
Publisher
Elsevier
Volume
147
Language
English
Type
ArticleItem Usage Stats
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Abstract
We consider the scheduling problem for biomanufacturing projects that involve multiple tasks and “no-wait” constraints between some of these tasks. The aim is to create schedules that ensure timely delivery of products while enabling schedule revisions to accommodate additional constraints realized during the execution of these projects. We formulate the problem as a mixed-integer linear programming model with the objective of minimizing total tardiness, and propose a dynamic scheduling approach that solves a series of modified mixed-integer linear programming models to revise and improve the schedule. We conduct numerical studies to investigate the performance of this approach and compare its performance to a traditional proactive scheduling approach. In collaboration with biomanufacturing companies, we create a scheduling tool and validate the approach with implementation in an industry setting.
Keywords
Dynamic schedulingBiomanufacturing
Protein manufacturing
No-wait
Mixed-integer linear program