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dc.contributor.authorTop, C. B.
dc.contributor.authorGüngör, Alper
dc.date.accessioned2021-02-18T10:57:59Z
dc.date.available2021-02-18T10:57:59Z
dc.date.issued2020
dc.identifier.issn0278-0062
dc.identifier.urihttp://hdl.handle.net/11693/75448
dc.description.abstractSuperparamagnetic iron oxide nanoparticles (SPIONs) have a high potential for use in clinical diagnostic and therapeutic applications. In vivo distribution of SPIONs can be imaged with the Magnetic Particle Imaging (MPI) method, which uses an inhomogeneous magnetic field with a field free region (FFR). The spatial distribution of the SPIONs are obtained by scanning the FFR inside the field of view (FOV) and sensing SPION related magnetic field disturbance. MPI magnets can be configured to generate a field free point (FFP), or a field free line (FFL) to scan the FOV. FFL scanners provide more sensitivity, and are also more suitable for scanning large regions compared to FFP scanners. Interventional procedures will benefit greatlyfrom FFL based open magnet configurations. Here, we present the first open-sided MPI system that can electronically scan the FOV with an FFL to generate tomographic MPI images. Magnetic field measurements show that FFL can be rotated electronically in the horizontal plane and translated in three dimensions to generate 3D MPI images. Using the developed scanner, we obtained 2D images of dot and cylinder phantoms with varying iron concentrations between 11 μg/ml and 770 μg/ml. We used a measurement based system matrix image reconstruction method that minimizes 11-norm and total variation in the images. Furthermore, we present 2D imaging results of two 4 mm-diameter vessel phantoms with 0% and 75% stenosis. The experiments show high quality imaging results with a resolution down to 2.5 mm for a relatively low gradient field of 0.6 T/m.en_US
dc.description.sponsorshipThis work was supported in part by the Scientific and Technological Research Council of Turkey (TUBITAK) under Grant 9050103.en_US
dc.language.isoEnglishen_US
dc.source.titleIEEE Transactions on Medical Imagingen_US
dc.relation.isversionofhttps://dx.doi.org/10.1109/TMI.2020.3014197en_US
dc.subjectMagnetic particle imagingen_US
dc.subjectField free lineen_US
dc.subjectOpen magnetic particle imaging scanneren_US
dc.subjectTomographyen_US
dc.subjectMagnetic nanoparticlesen_US
dc.titleTomographic field free line magnetic particle imaging with an open-sided scanner configurationen_US
dc.typeArticleen_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.citation.spage4164en_US
dc.citation.epage4173en_US
dc.citation.volumeNumber39en_US
dc.citation.issueNumber12en_US
dc.identifier.doi10.1109/TMI.2020.3014197en_US
dc.publisherIEEEen_US
dc.contributor.bilkentauthorGüngör, Alper


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