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dc.contributor.authorSarıtaş, Emine Ülküen_US
dc.contributor.authorLee, J.en_US
dc.contributor.authorNishimura, D.en_US
dc.date.accessioned2020-04-10T10:56:40Z
dc.date.available2020-04-10T10:56:40Z
dc.date.issued2011
dc.identifier.issn0278-0062
dc.identifier.urihttp://hdl.handle.net/11693/53594
dc.description.abstractOptimizing the diffusion-weighted imaging (DWI) parameters (i.e., the b -value and the number of image averages) to the tissue of interest is essential for producing high-quality apparent diffusion coefficient (ADC) maps. Previous investigation of this optimization was performed assuming Gaussian noise statistics for the ADC map, which is only valid for high signal-to-noise ratio (SNR) imaging. In this work, the true statistics of the noise in ADC maps are derived, followed by an optimization of the DWI parameters as a function of the imaging SNR. Specifically, it is demonstrated that the optimum b -value is a monotonically increasing function of the imaging SNR, which converges to the optimum b -value from previously proposed approaches for high-SNR cases, while exhibiting a significant deviation from this asymptote for low-SNR situations. Incorporating the effects of T 2 weighting further increases the SNR dependence of the optimal parameters. The proposed optimization scheme is particularly important for high-resolution DWI, which intrinsically suffers from low SNR and therefore cannot afford the use of the conventional high b -values. Comparison scans were performed for high-resolution DWI of the spinal cord, demonstrating the improvements in the resulting images and the ADC maps achieved by this method.en_US
dc.language.isoEnglishen_US
dc.source.titleIEEE Transactions on Medical Imagingen_US
dc.relation.isversionofhttps://doi.org/10.1109/TMI.2010.2084583en_US
dc.titleSNR dependence of optimal parameters for apparent diffusion coefficient measurementsen_US
dc.typeArticleen_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.citation.spage424en_US
dc.citation.epage437en_US
dc.citation.volumeNumber30en_US
dc.citation.issueNumber2en_US
dc.identifier.doi10.1109/TMI.2010.2084583en_US
dc.publisherIEEEen_US
dc.contributor.bilkentauthorSarıtaş, Emine Ülkü


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