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      Stability of local brain levels of insulin-like growth factor-I in two well-characterized models of decreased plasma IGF-I

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      Author(s)
      Adams, Michelle M.
      Forbes, M
      Linville, M.
      Riddle, D.
      Sonntag, W.
      Brunso-Bechtold, J.
      Date
      2009
      Source Title
      Growth Factors
      Print ISSN
      0897-7194
      Publisher
      Taylor & Francis
      Volume
      27
      Issue
      3
      Pages
      181 - 188
      Language
      English
      Type
      Article
      Item Usage Stats
      144
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      Abstract
      Insulin-like growth factor-I (IGF-I), a functionally important neurotrophic factor, impacts tissues throughout the body including the central nervous system. In addition to the significant proportion of IGF-I that is synthesized in the liver and released into the plasma, IGF-I is expressed locally in tissues. The present study investigated the relationship between plasma and local brain levels of IGF-I in two well-characterized models of decreased IGF-I. The first is an adult-onset growth hormone deficiency (AOGHD) model, and the second is a caloric restriction (CR) model. In the first cohort of animals from both models, the hippocampus was removed from the brain immediately following decapitation, and in the second cohort, the animals were perfused transcardially with phosphate buffered saline to remove cerebral blood prior to harvesting the hippocampus. Our results demonstrated that although the plasma IGF-I levels were decreased in the CR and AOGHD rats compared to controls, the hippocampal IGF-I levels did not differ among the groups. These data suggest that local brain IGF-I levels are regulated in a different manner than plasma IGF-I levels.
      Keywords
      Caloric restriction
      Dwarf rat
      Hippocampus
      Fischer 344 × Brown Norway rat
      Growth hormone
      Permalink
      http://hdl.handle.net/11693/53552
      Published Version (Please cite this version)
      https://doi.org/10.1080/08977190902863639
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