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dc.contributor.authorÇimenci, Çağla Eren
dc.contributor.authorUzunalli-Kurtuluş, G.
dc.contributor.authorÇalışkan, Özüm S.
dc.contributor.authorGüler, M. O.
dc.contributor.authorTekinay, Ayşe B.
dc.date.accessioned2020-02-14T07:55:34Z
dc.date.available2020-02-14T07:55:34Z
dc.date.issued2019
dc.identifier.issn1043-1802
dc.identifier.urihttp://hdl.handle.net/11693/53352
dc.description.abstractCadherins are vital for cell-to-cell interactions during tissue growth, migration, and differentiation processes. Both biophysical and biochemical inputs are generated upon cell-to-cell adhesions, which determine the fate of the mesenchymal stem cells (MSCs). The effect of cadherin interactions on the MSC differentiation still remains elusive. Here we combined the N-Cadherin mimetic peptide (HAV-PA) with the self-assembling E-PA and the resultant N-cadherin mimetic peptide nanofibers promoted chondrogenic differentiation of MSCs in conjunction with chondrogenic factors as a synthetic extracellular matrix system. Self-assembly of the precursor peptide amphiphile molecules HAV-PA and E-PA enable the organization of HAV peptide residues in close proximity to the cell interaction site, forming a supramolecular N-cadherin-like system. These bioactive peptide nanofibers not only promoted viability and enhanced adhesion of MSCs but also augmented the expression of cartilage specific matrix components compared to the nonbioactive control nanofibers. Overall, the N-cadherin mimetic peptide nanofiber system facilitated MSC commitment into the chondrogenic lineage presenting an alternative bioactive platform for stem-cell-based cartilage regeneration.en_US
dc.language.isoEnglishen_US
dc.source.titleBioconjugate Chemistryen_US
dc.relation.isversionofhttps://dx.doi.org/10.1021/acs.bioconjchem.9b00514en_US
dc.subjectNanofibersen_US
dc.subjectPeptides and proteinsen_US
dc.subjectGeneticsen_US
dc.subjectDifferentiationen_US
dc.subjectCellsen_US
dc.titleN-cadherin mimetic peptide nanofiber system induces chondrogenic differentiation of mesenchymal stem cellsen_US
dc.typeArticleen_US
dc.departmentInstitute of Materials Science and Nanotechnology UNAMen_US
dc.departmentInterdisciplinary Program in Neuroscienceen_US
dc.departmentNanotechnology Research Center NANOTAMen_US
dc.citation.spage2417en_US
dc.citation.epage2426en_US
dc.citation.volumeNumber30en_US
dc.citation.issueNumber9en_US
dc.identifier.doi10.1021/acs.bioconjchem.9b00514en_US
dc.publisherAmerican Chemical Societyen_US
dc.contributor.bilkentauthorÇimenci, Çağla Eren
dc.contributor.bilkentauthorÇalışkan, Özüm S.
dc.contributor.bilkentauthorTekinay, Ayşe B.


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