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      N-cadherin mimetic peptide nanofiber system induces chondrogenic differentiation of mesenchymal stem cells

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      Author(s)
      Çimenci, Çağla Eren
      Uzunalli-Kurtuluş, G.
      Çalışkan, Özüm S.
      Güler, M. O.
      Tekinay, Ayşe B.
      Date
      2019
      Source Title
      Bioconjugate Chemistry
      Print ISSN
      1043-1802
      Publisher
      American Chemical Society
      Volume
      30
      Issue
      9
      Pages
      2417 - 2426
      Language
      English
      Type
      Article
      Item Usage Stats
      187
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      383
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      Abstract
      Cadherins are vital for cell-to-cell interactions during tissue growth, migration, and differentiation processes. Both biophysical and biochemical inputs are generated upon cell-to-cell adhesions, which determine the fate of the mesenchymal stem cells (MSCs). The effect of cadherin interactions on the MSC differentiation still remains elusive. Here we combined the N-Cadherin mimetic peptide (HAV-PA) with the self-assembling E-PA and the resultant N-cadherin mimetic peptide nanofibers promoted chondrogenic differentiation of MSCs in conjunction with chondrogenic factors as a synthetic extracellular matrix system. Self-assembly of the precursor peptide amphiphile molecules HAV-PA and E-PA enable the organization of HAV peptide residues in close proximity to the cell interaction site, forming a supramolecular N-cadherin-like system. These bioactive peptide nanofibers not only promoted viability and enhanced adhesion of MSCs but also augmented the expression of cartilage specific matrix components compared to the nonbioactive control nanofibers. Overall, the N-cadherin mimetic peptide nanofiber system facilitated MSC commitment into the chondrogenic lineage presenting an alternative bioactive platform for stem-cell-based cartilage regeneration.
      Keywords
      Nanofibers
      Peptides and proteins
      Genetics
      Differentiation
      Cells
      Permalink
      http://hdl.handle.net/11693/53352
      Published Version (Please cite this version)
      https://dx.doi.org/10.1021/acs.bioconjchem.9b00514
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 228
      • Institute of Materials Science and Nanotechnology (UNAM) 2098
      • Nanotechnology Research Center (NANOTAM) 1125
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