Cucurbituril-anchored porphyrin-based multifunctional molecular platform for photodynamic antimicrobial and cancer therapy
Hadi, Seyed E.
ACS Applied Bio Materials
American Chemical Society
4693 - 4697
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Here we report a photoactive supramolecular assembly that is multifunctional and constructed by covalently linking four receptor molecules (cucurbituril) to a porphyrin derivative with suitable linkers. While this molecular platform serves very efficiently as a light-triggered broad-spectrum antibacterial agent, owing to its negligible dark cytotoxicity and the presence of host molecules (CB7), it can also be utilized as a vehicle to carry drug molecules for a combined chemo and photodynamic cancer therapy.
KeywordsChemo-photodynamic dual cancer therapy
Multifunctional molecular platform
Photodynamic antimicrobial therapy