Relaxation-based color magnetic particle imaging for viscosity mapping
Author
Utkur, Mustafa
Muslu, Yavuz
Sarıtaş, Emine Ülkü
Date
2019Source Title
Applied Physics Letters
Print ISSN
0003-6951
Publisher
American Institute of Physics
Volume
115
Issue
15
Pages
152403-1 - 152403-5
Language
English
Type
ArticleItem Usage Stats
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Abstract
Magnetic particle imaging (MPI) uses superparamagnetic iron oxide (SPIO) nanoparticles as biomedical imaging tracers. The potential applications of MPI have recently been broadened by the introduction of “color” MPI techniques that can distinguish different nanoparticles and/or environments, e.g., by exploiting the relaxation behavior of SPIOs. One of the important applications of color MPI techniques is viscosity mapping. In this work, we show relaxation-based color MPI experiments that can distinguish the biologically relevant viscosity range of up to 5 mPa s. To find the optimal drive field parameters for viscosity, we compare color MPI results at three different frequencies. We show that frequencies around 10 kHz are well-suited for viscosity mapping using the multicore cluster Nanomag-MIP nanoparticles, providing a one-to-one mapping between the estimated relaxation time constant and viscosity.
Keywords
Electromagnetic coilsRelaxation method
Medical imaging
Image processing
Viscosity measurements
Nanoparticles