PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus

Limited Access
This item is unavailable until:
2020-05-01
Date
2019
Editor(s)
Advisor
Supervisor
Co-Advisor
Co-Supervisor
Instructor
Source Title
Journal of Autoimmunity
Print ISSN
0896-8411
Electronic ISSN
Publisher
Elsevier
Volume
99
Issue
Pages
24 - 32
Language
English
Journal Title
Journal ISSN
Volume Title
Series
Abstract

In this manuscript, we employ interface enhanced computational homogenization to explore and detail on a number of unfamiliar characteristics that composites can exhibit at different length scales. Here, the interface between the constituents is general in the sense that both displacement and traction jumps across the interface are admissible. We carry out numerous computational investigations using the finite element method for a broad range of various material parameters. Our numerical results reveal that the effective response of a microstructure embedding general interfaces is intuitively unpredictable and highly complex. In particular, for certain ranges of material parameters the overall response shows insensitivity with respect to either microstructure size or stiffness-ratio between inclusion and matrix. This unique behavior is observed likewise for two- and three-dimensional unit-cells. Our findings provide a valuable guideline to design tunable composites utilizing interfaces.

Course
Other identifiers
Book Title
Citation
Published Version (Please cite this version)