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      An integrated genomic and metabolomic approach for defining survival time in adult oligodendrogliomas patients

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      Author(s)
      Bund, C.
      Guergova‑Kuras, M.
      Çiçek, A. Ercüment
      Moussallieh, F.-M.
      Dali‑Youcef, N.
      Piotto, M.
      Schneider, P.
      Heller, R.
      Entz‑Werle, N.
      Lhermitte, B.
      Chenard, M.-P.
      Schott, R.
      Proust, F.
      Noel, G.
      Namer, I. J.
      Date
      2019
      Source Title
      Metabolomics
      Print ISSN
      1573-3882
      Publisher
      Springer
      Volume
      15
      Pages
      69-1 - 69-11
      Language
      English
      Type
      Article
      Item Usage Stats
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      Abstract
      Introduction The identification of frequent acquired mutations shows that patients with oligodendrogliomas have divergent biology with differing prognoses regardless of histological classification. A better understanding of molecular features as well as their metabolic pathways is essential. Objectives The aim of this study was to examine the relationship between the tumor metabolome, six genomic aberrations (isocitrate dehydrogenase1 [IDH1] mutation, 1p/19q codeletion, tumor protein p53 [TP53] mutation, O6-methylguanin-DNA methyltransferase [MGMT] promoter methylation, epidermal growth factor receptor [EGFR] amplification, phosphate and tensin homolog [PTEN] methylation), and the patients’ survival time. Methods We applied 1H high-resolution magic-angle spinning (HRMAS) nuclear magnetic resonance (NMR) spectroscopy to 72 resected oligodendrogliomas. Results The presence of IDH1, TP53, 1p19q codeletion, MGMT promoter methylation reduced the relative risk of death, whereas PTEN methylation and EGFR amplification were associated with poor prognosis. Increased concentration of 2-hydroxyglutarate (2HG), N-acetyl-aspartate (NAA), myo-inositol and the glycerophosphocholine/phosphocholine (GPC/ PC) ratio were good prognostic factors. Increasing the concentration of serine, glycine, glutamate and alanine led to an increased relative risk of death. Conclusion HRMAS NMR spectroscopy provides accurate information on the metabolomics of oligodendrogliomas, making it possible to find new biomarkers indicative of survival. It enables rapid characterization of intact tissue and could be used as an intraoperative method.
      Keywords
      HRMAS-NMR spectroscopy
      Metabolomics
      Oligodendroglioma
      Overall survival
      IDH
      PTEN
      Permalink
      http://hdl.handle.net/11693/52993
      Published Version (Please cite this version)
      https://dx.doi.org/10.1007/s11306-019-1522-5
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      • Department of Computer Engineering 1510
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