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dc.contributor.advisorElbüken, Çağlaren_US
dc.contributor.authorSaateh, Abtinen_US
dc.date.accessioned2019-09-09T08:13:42Z
dc.date.available2019-09-09T08:13:42Z
dc.date.copyright2019-08
dc.date.issued2019-08
dc.date.submitted2019-08-29
dc.identifier.urihttp://hdl.handle.net/11693/52391
dc.descriptionCataloged from PDF version of article.en_US
dc.descriptionThesis (M.S.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2019.en_US
dc.descriptionIncludes bibliographical references (leaves 78-88).en_US
dc.description.abstractDroplet-based micro uidic systems require a precise control on droplet physical properties, hence measuring the morphological properties of droplets is critical to obtain high sensitivity analysis. The ability to perform such measurements in real-time is another demand which has not been addressed yet. In this study, coplanar electrodes were used, and con gured in di erential measurement mode for impedimetric measurement of size and velocity. To obtain the size of the droplets, detailed 3D nite element simulations of the system were performed. The interaction of the non-uniform electric eld and the droplet was investigated. The electrode geometry optimization steps were described and design guideline rules were laid out. Size of the electrodes was optimized based on the simulations for droplet lengths ranging from 300 to 1500 μm. A user-friendly software was developed for real-time observation of droplet length and velocity together with in-situ statistical analysis results. A detailed comparison between impedimetric and optical measurement tools is given. Finally, to illustrate the bene t of having real-time analysis, iDM was used for experimental studies. First study case is the response time of the syringe pump and pressure pump driven droplet generation devices. This analysis allows one to evaluate the `warm-up' time for a droplet generator system after which droplets reach the desired stead-state size required by the assay of interest. Second, an evaluation chip was designed to investigate e ective factors and their interplay with droplet length variation. A comprehensive design of experiment (DoE) method is utilized. Analyzing the obtained results revealed e ect of each factor and their interactions. Exploiting results of this study contributes to monodisperse micro uidic droplet generation. Monodisperse polymeric particles of polyethylene glycol were synthesized to demonstrate the potentials of monodisperse droplet generation in biochemical synthesis/analysis.en_US
dc.description.statementofresponsibilityby Abtin Saatehen_US
dc.format.extentxv, 95 leaves : illustrations, charts (some colour) ; 30 cm.en_US
dc.language.isoEnglishen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDroplet microfluidicsen_US
dc.subjectReal-timeen_US
dc.subjectDroplet measurementen_US
dc.subjectImpedimetricen_US
dc.subjectLabel-freeen_US
dc.subjectDroplet monodispersityen_US
dc.titleReal-time impedimetric microfluidic droplet measurement: IDMen_US
dc.title.alternativeGerçek zamanlı impedimetrik mikroakışkan damlackı ölçümü: IDMen_US
dc.typeThesisen_US
dc.departmentInstitute of Materials Science and Nanotechnology UNAMen_US
dc.publisherBilkent Universityen_US
dc.description.degreeM.S.en_US
dc.identifier.itemidB120819
dc.embargo.release2020-02-29


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