dc.contributor.advisor | Elbüken, Çağlar | |
dc.contributor.author | Saateh, Abtin | |
dc.date.accessioned | 2019-09-09T08:13:42Z | |
dc.date.available | 2019-09-09T08:13:42Z | |
dc.date.copyright | 2019-08 | |
dc.date.issued | 2019-08 | |
dc.date.submitted | 2019-08-29 | |
dc.identifier.uri | http://hdl.handle.net/11693/52391 | |
dc.description | Cataloged from PDF version of article. | en_US |
dc.description | Thesis (M.S.): Bilkent University, Department of Materials Science and Nanotechnology, İhsan Doğramacı Bilkent University, 2019. | en_US |
dc.description | Includes bibliographical references (leaves 78-88). | en_US |
dc.description.abstract | Droplet-based micro
uidic systems require a precise control on droplet physical
properties, hence measuring the morphological properties of droplets is critical
to obtain high sensitivity analysis. The ability to perform such measurements in
real-time is another demand which has not been addressed yet. In this study,
coplanar electrodes were used, and con gured in di erential measurement mode
for impedimetric measurement of size and velocity. To obtain the size of the
droplets, detailed 3D nite element simulations of the system were performed.
The interaction of the non-uniform electric eld and the droplet was investigated.
The electrode geometry optimization steps were described and design guideline
rules were laid out. Size of the electrodes was optimized based on the simulations
for droplet lengths ranging from 300 to 1500 μm. A user-friendly software was
developed for real-time observation of droplet length and velocity together with
in-situ statistical analysis results. A detailed comparison between impedimetric
and optical measurement tools is given. Finally, to illustrate the bene t of
having real-time analysis, iDM was used for experimental studies. First study
case is the response time of the syringe pump and pressure pump driven droplet
generation devices. This analysis allows one to evaluate the `warm-up' time for a
droplet generator system after which droplets reach the desired stead-state size
required by the assay of interest. Second, an evaluation chip was designed to
investigate e ective factors and their interplay with droplet length variation. A
comprehensive design of experiment (DoE) method is utilized. Analyzing the
obtained results revealed e ect of each factor and their interactions. Exploiting
results of this study contributes to monodisperse micro
uidic droplet generation.
Monodisperse polymeric particles of polyethylene glycol were synthesized
to demonstrate the potentials of monodisperse droplet generation in biochemical
synthesis/analysis. | en_US |
dc.description.statementofresponsibility | by Abtin Saateh | en_US |
dc.format.extent | xv, 95 leaves : illustrations, charts (some colour) ; 30 cm. | en_US |
dc.language.iso | English | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Droplet microfluidics | en_US |
dc.subject | Real-time | en_US |
dc.subject | Droplet measurement | en_US |
dc.subject | Impedimetric | en_US |
dc.subject | Label-free | en_US |
dc.subject | Droplet monodispersity | en_US |
dc.title | Real-time impedimetric microfluidic droplet measurement: IDM | en_US |
dc.title.alternative | Gerçek zamanlı impedimetrik mikroakışkan damlackı ölçümü: IDM | en_US |
dc.type | Thesis | en_US |
dc.department | Institute of Materials Science and Nanotechnology UNAM | en_US |
dc.publisher | Bilkent University | en_US |
dc.description.degree | M.S. | en_US |
dc.identifier.itemid | B120819 | |
dc.embargo.release | 2020-02-29 | |