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      • Bilkent Theses
      • Theses - Department of Computer Engineering
      • Dept. of Computer Engineering - Master's degree
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      Analyzing the effect of kinship for re-identification attacks in genomic data sharing beacons

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      Author(s)
      Ayşen, Miray
      Advisor
      Ayday, Erman
      Date
      2019-08
      Publisher
      Bilkent University
      Language
      English
      Type
      Thesis
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      Abstract
      Genomic data contains sensitive information about an individual. Family members' genome sequence can be re-constructed with high confidence or individuals' may face discrimination because of predisposition of a disease if genome sequence of a person is obtained. To protect the genomic information and provide a standardize and secure way for using this data the \Beacon project" initiated. Studies show that the genomic data sharing beacons are vulnerable to re-identification attacks. Since beacons generally constructed based on types of diseases, re-identification creates a significant risk for individuals. On the other hand, genomic data enables researchers to find the cause of diseases and improves personalized medicine. Previously proposed counter measures against re-identification attacks proved to be not effective as earlier researches show. In this thesis, we analyze the kin relationships' effect on the genomic data sharing beacons. Our study is based on the fact that kinship may be misleading for re-identification attacks since same SNPs can be appear in multiple family members. We showed that adding at least one of the parents to the beacon (i) cause significant decrease in the power of attacks and (ii) increase in the number of queries needed to confirm an individual's beacon membership. To investigate the suitability of using kinship as a counter measure for beacons we also calculate the utility decrease. We further show the effects of adding more distant relatives to the beacon such as grandparents.
      Keywords
      Beacon
      Genome privacy
      Counter measure
      Permalink
      http://hdl.handle.net/11693/52356
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      • Dept. of Computer Engineering - Master's degree 566
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