Nanoparticle labeling: a new era in vivo tracing the cells in liver studies
Journal of HepatologyAbstracts of the International Liver Congress 2012: 47th Annual Meeting of the European Association for the Study of the Liver
162 - 163
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Tracking molecules in vivo has always been challenging and there is increasing demand for tools that allow researchers to trace especially during cell-based therapies. Conjugated polymer based water-dispersible nanoparticles (NP) represent a new class of probes for cell imaging and tracking because they offer high brightness, improved photostability, high fluorescent quantum yield and non-cytotoxicity comparing to conventional dyes. We aimed to develop a novel approach by using fluorescein emitting NP to label Mesenchymal Stem Cells (MSCs) and HUH7 cell lines and assess their fate in vivo in liver regeneration, liver fibrosis and xenografts.