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      Conjugated polymer nanoparticles for cell labelling, imaging and drug delivery

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      Author(s)
      Tuncel, Dönüş
      İbrahimova, Vusela
      Gezici, Özlem
      Date
      2012-08
      Source Title
      4th EuCheMS Chemistry Congress, 2012
      Publisher
      European Association for Chemical and Molecular Sciences
      Language
      English
      Type
      Conference Paper
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      Abstract
      Nanoparticles based on conjugated polymers are emerging as a new class of luminescent nanoparticles. These nanoparticles have many potential applications including imaging agents, biosensors, and photonics owing to their high quantum yields, high molar absorptivity, photo stability and easy synthesis. The recent cell assay studies have also showed that these nanoparticles were not cytotoxic.4Moreover, conjugated polymer nanoparticles can be modified easily to deliver therapeutic agents such as cancer drugs, genetic materials (e.g. RNA, siRNA) and biomolecules to the desired targets. Here, we present the resent studies in our lab involving the synthesis and applications of nanoparticles using various conjugated polymers which emit blue, green, yellow and red. In order to obtain shape-persistent and stable nanoparticles, a novel method was developed in which the nanoparticles were prepared either via Cu-catalyzed or cucurbit[6]uril (CB6)-catalyzed click reactions between azide groups containing hydrophobic fluorene-based conjugated polymers and a hydrophilic diaminodialkyne containing cross-linker. Through the click reaction, not only does the cross-linking confer stability, but it also introduces functional groups, such as triazoles and amines, to the nanoparticles. TEM images of the nanoparticles also showed that they display very interesting morphologies. Incorporation of hydrophilic functional groups to the hydrophobic conjugated polymers resulted in a distinct phase separation, producing Janus-like or patchy particles.
      Keywords
      Nanoparticles
      Nanotechnology
      Polymers
      Drug delivery
      Fluorescent nanoparticles
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      http://hdl.handle.net/11693/52248
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