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dc.contributor.authorYıldız, Gökhanen_US
dc.contributor.authorÖztürk, Mehmeten_US
dc.coverage.spatialBerlin, Germanyen_US
dc.date.accessioned2019-07-10T06:54:18Z
dc.date.available2019-07-10T06:54:18Z
dc.date.issued2012-09en_US
dc.identifier.urihttp://hdl.handle.net/11693/52238
dc.descriptionConference Name: 6th Annual Conference of the International Liver Cancer Association, ILCA 2012en_US
dc.descriptionDate of Conference: 14-16 September 2012en_US
dc.description.abstractEpigenetic mechanisms are involved in the organization of chromatin structure and global regulation of gene expression [1]. Cancer cells display multiple epigenetic changes including aberrations in the methylation of DNA, expression of non-coding RNA s and posttranslational modifications of histones [1,2]. Epigenetic changes appear to play a major role in liver cancer [3], one of the rare malignancies that can be induced by dietary restriction of methyl donors. Furthermore, global DNA hypomethylation and selective promoter hypermethylation of a large set of genes affect these cancers. Recently, mutations of ARID1a and ARID2 genes involved in chromatin remodeling have also been reported [4], but a systematic study of the status of epigenetic regulatory genes is lacking. Our aim was to identify epigenetic regulatory genes associated with liver cancer.en_US
dc.language.isoEnglishen_US
dc.source.title6th Annual Conference of the International Liver Cancer Association, ILCA 2012en_US
dc.titleDifferential expression of epigenetic regulatory genes in liver canceren_US
dc.typeConference Paperen_US
dc.departmentDepartment of Molecular Biology and Geneticsen_US
dc.citation.spage99en_US
dc.publisherInternational Liver Cancer Associationen_US


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