Bacteriocin DNA nanocomplexes as immunotherapeutic carriers
Yağcı, Fuat Cem
Abstract Book 2012, 10th CIMT Annual Meeting
Association for Cancer Immunotherapy
136 - 137
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Synthetic oligodeoxynucleotides (CpG-ODNs) and bacterial DNA containing unmethylated CpG dinucleotides (CpG motifs) are clinical candidates as anti-cancer agents, immune adjuvants, anti-allergens, and stand alone immunoprotective agents. Two different classes of CpG-ODNs were identified for clinical applications. B-Class ODNs, also known as K-type CpG ODN, have phosphorothioate backbones and potent B- cell activators. A-Class ODNs (or D-type ODNs) have mixed backbone and flanking G-runs at their 3`and 5-ends.