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      • Department of Molecular Biology and Genetics
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      Bacteriocin DNA nanocomplexes as immunotherapeutic carriers

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      Author(s)
      Yağcı, Fuat Cem
      Güçlüler, Gözde
      Kıran, F.
      Gürsel, İhsan
      Date
      2012-05
      Source Title
      Abstract Book 2012, 10th CIMT Annual Meeting
      Publisher
      Association for Cancer Immunotherapy
      Pages
      136 - 137
      Language
      English
      Type
      Conference Paper
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      Abstract
      Synthetic oligodeoxynucleotides (CpG-ODNs) and bacterial DNA containing unmethylated CpG dinucleotides (CpG motifs) are clinical candidates as anti-cancer agents, immune adjuvants, anti-allergens, and stand alone immunoprotective agents. Two different classes of CpG-ODNs were identified for clinical applications. B-Class ODNs, also known as K-type CpG ODN, have phosphorothioate backbones and potent B- cell activators. A-Class ODNs (or D-type ODNs) have mixed backbone and flanking G-runs at their 3`and 5-ends.
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      http://hdl.handle.net/11693/52144
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