Bacteriocin DNA nanocomplexes as immunotherapeutic carriers
Date
2012-05Source Title
Abstract Book 2012, 10th CIMT Annual Meeting
Publisher
Association for Cancer Immunotherapy
Pages
136 - 137
Language
English
Type
Conference PaperItem Usage Stats
157
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36
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Abstract
Synthetic oligodeoxynucleotides (CpG-ODNs) and bacterial DNA containing unmethylated CpG dinucleotides (CpG motifs) are clinical candidates as anti-cancer agents, immune adjuvants, anti-allergens, and stand alone immunoprotective agents. Two different classes of CpG-ODNs were identified for clinical applications. B-Class ODNs, also known as K-type CpG ODN, have phosphorothioate backbones and potent B- cell activators. A-Class ODNs (or D-type ODNs) have mixed backbone and flanking G-runs at their 3`and 5-ends.