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      Zebrafish aging models and possible interventions

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      Author
      Birand, Dilan Ç.
      Erbaba, Begün
      Özdemir, Ahmet T.
      Kafalıgönül, Hulusi
      Adams, Michelle
      Editor
      Bozkurt, Y.
      Date
      2018
      Publisher
      InTechOpen Press
      Pages
      3 - 26
      Language
      English
      Type
      Book Chapter
      Item Usage Stats
      183
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      114
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      Book Title
      Recent advances in zebrafish researches
      Abstract
      Across the world, the aging population is expanding due to an increasing average life expectancy. The percentage of elderly over the age of 65 is expected to be more than 15% of the total world population by 2025. As the lifespan increases, there will be a need for maintaining a healthy state for these individuals. Our current knowledge on types and durations of potential anti-aging therapies is quite limited. Recently the zebrafish has emerged as a promising model for understanding the cognitive and neurobiological changes during aging, as well as its use with potential anti-aging interventions. Like humans this model organism ages gradually, displays similar behavioral properties and social characteristics, and in addition, there is a wealth of molecular and genetic tools to uncover the cellular mechanism that contribute to age-related cognitive declines. Drug effect and toxicity can be easily tested in the zebrafish. Therefore, this animal model can provide information about potential therapies that could be translated directly into human populations or provide a more focused treatment direction for testing in other mammalian animal models. The zebrafish will be a powerful tool for uncovering the mysteries of the aging brain.
      Keywords
      Aging
      Behavior
      Neurobiology
      Dietary regimens
      Rapamycin
      Morpholino
      Zebrafish aging models
      Permalink
      http://hdl.handle.net/11693/51967
      Published Version (Please cite this version)
      http://dx.doi.org/10.5772/intechopen.75554
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 196
      • Department of Molecular Biology and Genetics 442
      • Department of Psychology 167
      • Institute of Materials Science and Nanotechnology (UNAM) 1831
      • National Magnetic Resonance Research Center (UMRAM) 195
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