Nanomaterials for neural regeneration
Author
Sever, Melike
Mammadov, Büşra
Geçer, Mevhibe
Güler, Mustafa O.
Tekinay, Ayşe B.
Editor
Güler, Mustafa O.
Tekinay, Ayşe B.
Date
2016-03-11Publisher
John Wiley & Sons
Pages
33 - 58
Language
English
Type
Book ChapterItem Usage Stats
191
views
views
129
downloads
downloads
Book Title
Therapeutic nanomaterials
Abstract
The central nervous system (CNS) consists of a dense network of cells leaving a smaller volume for the extracellular matrix (ECM) components (10‐20% for the brain unlike most other tissues (Cragg, 1979)). The reaction of the nervous tissue to any injury leading to scar tissue formation acts as a barrier for regeneration in the CNS, while it supports regeneration in the peripheral nervous system (PNS). By mimicking several unique characteristics of the natural environment of cells, synthetic materials for neural regeneration can be improved chemically and biologically. Especially bioactivation of materials can be achieved by addition of small chemical moieties to the scaffold particularly found in specific tissues or addition of biologically active molecules derived from natural ECM. The ECM‐derived short peptides are promising candidates to be presented as functional domains on the scaffold surface for use in neural regeneration.
Keywords
Biological functionalizationCellular behavior
Central nervous system
Chemical functionalization
Electrical conductivity
Extracellular matrix
Nanomaterials
Neural regeneration
Peripheral nervous system
Permalink
http://hdl.handle.net/11693/50839Published Version (Please cite this version)
https://doi.org/10.1002/9781118987483.ch3https://doi.org/10.1002/9781118987483