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      Biocompatible electroactive tetra (aniline)-conjugated peptide nanofibers for neural differentiation

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      Author
      Arioz, Idil
      Erol, Ozlem
      Bakan, Gokhan
      Dikecoglu, F. Begum
      Topal, Ahmet E.
      Urel, Mustafa
      Dana, Aykutlu
      Tekinay, Ayse B.
      Güler, Mustafa O.
      Date
      2018
      Source Title
      ACS Applied Materials and Interfaces
      Print ISSN
      1944-8244
      Publisher
      American Chemical Society
      Volume
      10
      Issue
      1
      Pages
      308 - 317
      Language
      English
      Type
      Article
      Item Usage Stats
      172
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      231
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      Abstract
      Peripheral nerve injuries cause devastating problems for the quality of patients' lives, and regeneration following damage to the peripheral nervous system is limited depending on the degree of the damage. Use of nanobiomaterials can provide therapeutic approaches for the treatment of peripheral nerve injuries. Electroactive biomaterials, in particular, can provide a promising cure for the regeneration of nerve defects. Here, a supramolecular electroactive nanosystem with tetra(aniline) (TA)-containing peptide nanofibers was developed and utilized for nerve regeneration. Self-assembled TA-conjugated peptide nanofibers demonstrated electroactive behavior. The electroactive self-assembled peptide nanofibers formed a well-defined three-dimensional nanofiber network mimicking the extracellular matrix of the neuronal cells. Neurite outgrowth was improved on the electroactive TA nanofiber gels. The neural differentiation of PC-12 cells was more advanced on electroactive peptide nanofiber gels, and these biomaterials are promising for further use in therapeutic neural regeneration applications.
      Keywords
      Electroactive nanofibers
      Neural regeneration
      Oligo (aniline)
      Peptide amphiphiles
      Self-assembly
      Tetra (aniline)
      Permalink
      http://hdl.handle.net/11693/49992
      Published Version (Please cite this version)
      https://doi.org/10.1021/acsami.7b16509
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 200
      • Institute of Materials Science and Nanotechnology (UNAM) 1881
      • Nanotechnology Research Center (NANOTAM) 1046
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