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dc.contributor.authorAlipour, Akbaren_US
dc.contributor.authorSoran-Erdem, Zelihaen_US
dc.contributor.authorUtkur, Mustafaen_US
dc.contributor.authorSharma, Vijay Kumaren_US
dc.contributor.authorAlgın, Oktayen_US
dc.contributor.authorSarıtaş, Emine Ülküen_US
dc.contributor.authorDemir, Hilmi Volkanen_US
dc.date.accessioned2019-02-21T16:01:50Z
dc.date.available2019-02-21T16:01:50Z
dc.date.issued2018en_US
dc.identifier.issn0730-725X
dc.identifier.urihttp://hdl.handle.net/11693/49926
dc.description.abstractSuperparamagnetic iron oxide nanoparticles (SPIONs) are widely used as a robust negative contrast agent on conventional MRI. In this study, we (a) synthesized a new class of cubic SPIONs as a dual-mode contrast agent in MRI and (b) showed the in-vivo feasibility of these nanaoparticles as a simultaneous positive and negative contrast agent. Relaxation properties and contrast enhancement analysis of the synthesized SPIONs with two different shapes (cubic vs. spherical) and three different sizes 7 nm, 11 nm, and 14 nm were investigated to evaluate contrast enhancement in-vitro. In-vivo MRI experiments were performed on a 3T MR scanner, where a healthy anesthetized rat was imaged before, and from 20 to 80 min after intravenous injection of 1 mg/kg of contrast agent. Representative transmission electron microscopy (TEM) images of the synthesized nanoparticles reveal that the particles are well dispersed in a solvent and do not aggregate. The in-vitro relaxivity and contrast enhancement analysis show that, among all six SPIONs tested, 11-nm cubic SPIONs possess optimal molar relaxivities and contrast enhancement values, which can shorten the spin-lattice and spin-spin relaxation times, simultaneously. No noticeable toxicity is observed during in-vitro cytotoxicity analysis. In-vivo T1-and T2-weighted acquisitions at 60-min post-injection of 11-nm cubic SPIONs result in 64% and 48% contrast enhancement on the T1-and T2-weighted images, respectively. By controlling the shape and size of SPIONs, we have introduced a new class of cubic SPIONs as a synergistic (dual-mode) MRI contrast agent. 11-nm cubic SPIONs with smaller size and high positive and negative contrast enhancements were selected as a promising candidate for dual-mode contrast agent. Our proof-of-concept MRI experiments on rat demonstrate the in-vivo dual-mode contrast enhancement feasibility of these nanoparticles.
dc.description.sponsorshipWe gratefully acknowledge Dr. Gamze Aykut, Department of Molecular Biology and Genetics, Bilkent University, Ankara, Taner Demir and Dr. Volkan Acikel, Bilkent University, Ankara, for their assistance in in-vivo experiments, and all UMRAM staff for providing technical support. The authors also gratefully thank scientific discussion of Dr. Tolga Cukur. We would like to acknowledge Biomaten (METU) for the cytotoxicity experiments.
dc.language.isoEnglish
dc.source.titleMagnetic Resonance Imagingen_US
dc.relation.isversionofhttps://doi.org/10.1016/j.mri.2017.09.013
dc.subjectContrast enhancementen_US
dc.subjectDual-mode MRI contrast agentsen_US
dc.subjectMRI relaxivityen_US
dc.subjectSuperparamagnetic iron oxide nanoparticlesen_US
dc.titleA new class of cubic SPIONs as a dual-mode T1 and T2 contrast agent for MRIen_US
dc.typeArticleen_US
dc.departmentDepartment of Electrical and Electronics Engineeringen_US
dc.departmentNational Magnetic Resonance Research Center (UMRAM)en_US
dc.departmentNanotechnology Research Center (NANOTAM)en_US
dc.departmentDepartment of Physicsen_US
dc.departmentInterdisciplinary Program in Neuroscience (NEUROSCIENCE)en_US
dc.departmentAysel Sabuncu Brain Research Center (BAM)en_US
dc.citation.spage16en_US
dc.citation.epage24en_US
dc.citation.volumeNumber49en_US
dc.relation.projectBilkent Üniversitesi
dc.identifier.doi10.1016/j.mri.2017.09.013
dc.publisherElsevier
dc.contributor.bilkentauthorAlipour, Akbar
dc.contributor.bilkentauthorSoran-Erdem, Zeliha
dc.contributor.bilkentauthorUtkur, Mustafa
dc.contributor.bilkentauthorSharma, Vijay Kumar
dc.contributor.bilkentauthorAlgın, Oktay
dc.contributor.bilkentauthorSarıtaş, Emine Ülkü
dc.contributor.bilkentauthorDemir, Hilmi Volkan
dc.embargo.release2019-06-01en_US
dc.identifier.eissn1873-5894
buir.contributor.orcidDemir, Hilmi Volkan|0000-0003-1793-112Xen_US


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