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      Protective therapeutic effects of peptide nanofiber and hyaluronic acid hybrid membrane in in vivo osteoarthritis model

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      Author(s)
      Arslan, Elif
      Ekiz, Melis Sardan
      Cimenci, Cagla Eren
      Can, N.
      Gemci, M. H.
      Ozkan, H.
      Güler, Mustafa O.
      Tekinay, Ayse B.
      Date
      2018
      Source Title
      Acta Biomaterialia
      Print ISSN
      1742-7061
      Publisher
      Acta Materialia Inc
      Volume
      73
      Pages
      263 - 274
      Language
      English
      Type
      Article
      Item Usage Stats
      145
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      286
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      Abstract
      Osteoarthritis (OA) is a condition where tissue function is lost through a combination of secondary inflammation and deterioration in articular cartilage. One of the most common causes of OA is age-related tissue impairment because of wear and tear due to mechanical erosion. Hyaluronic acid-based viscoelastic supplements have been widely used for the treatment of knee injuries. However, the current formulations of hyaluronic acid are unable to provide efficient healing and recovery. Here, a nanofiber-hyaluronic acid membrane system that was prepared by using a quarter of the concentration of commercially available hyaluronic acid supplement, Hyalgan® was used for the treatment of an osteoarthritis model, and Synvisc® which is another commercially available hyaluronic acid containing viscoelastic supplement, was used as a control. The results show that this system provides efficient protection of arthritic cartilage tissue through the preservation of cartilage morphology with reduced osteophyte formation, protection of the subchondral region from deterioration, and maintenance of cartilage specific matrix proteins in vivo. In addition, the hybrid nanofiber membrane enabled chondrocyte encapsulation and provided a suitable culturing environment for stem cell growth in vitro. Overall, our results suggest that this hybrid nanofibrous scaffold provides a potential platform the treatment of OA. Statement of Significance: Osteoarthritis is a debilitating joint disease affecting millions of people worldwide. It occurs especially in knees due to aging, sport injuries or obesity. Although hyaluronic acid-based viscoelastic supplements are widely used, there is still no effective treatment method for osteoarthritis, which necessitates surgical operation as an only choice for severe cases. Therefore, there is an urgent need for efficient therapeutics. In this study, a nanofiber-HA membrane system was developed for the efficient protection of arthritic cartilage tissue from degeneration. This hybrid nanofiber system provided superior therapeutic activity at a relatively lower concentration of hyaluronic acid than Hyalgan® and Synvisc® gels, which are currently used in clinics. This work demonstrates for the first time that this hybrid nanofiber membrane scaffold can be utilized as a potential candidate for osteoarthritis treatment.
      Keywords
      Hyaluronic acid
      Hybrid membrane
      Osteoarthritis model
      Peptide gel
      Protection
      Permalink
      http://hdl.handle.net/11693/49830
      Published Version (Please cite this version)
      https://doi.org/10.1016/j.actbio.2018.04.015
      Collections
      • Aysel Sabuncu Brain Research Center (BAM) 213
      • Institute of Materials Science and Nanotechnology (UNAM) 1930
      • Nanotechnology Research Center (NANOTAM) 1063
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