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dc.contributor.authorAndrea, J.en_US
dc.contributor.authorPicchionib, M.en_US
dc.contributor.authorZhang, R.en_US
dc.contributor.authorToulopoulou, T.en_US
dc.date.accessioned2019-02-04T11:33:51Z
dc.date.available2019-02-04T11:33:51Z
dc.date.issued2016-02en_US
dc.identifier.issn1053-8119
dc.identifier.urihttp://hdl.handle.net/11693/48798
dc.description.abstractWorking memoryability maturesthroughpubertyand early adulthood. Deficits inworkingmemoryare linkedtothe risk of onset of neurodevelopmental disorders such as schizophrenia, and there is a significant temporal over-lap between the peak offirst episodepsychosisrisk and working memorymaturation. Inorder to characterize thenormal working memory functional maturation process through this critical phase of cognitive development weconducted a systematic review and coordinate based meta-analyses of all the available primary functional mag-netic resonance imaging studies (n = 382) that mapped WM function in healthy adolescents (10–17 years) andyoung adults (18–30 years). Activation Likelihood Estimation analyses across all WMtasks revealed increased ac-tivation with increasing subject age in the middle frontal gyrus (BA6) bilaterally, the left middle frontal gyrus(BA10), the left precuneus and left inferior parietal gyri (BA7; 40). Decreased activation with increasing agewas found in the right superior frontal (BA8), left junction of postcentral and inferior parietal (BA3/40), andleft limbic cingulate gyrus (BA31). These results suggest that brain activation during adolescence increasedwith age principally in higher order cortices, part of the core working memory network, while reductions weredetected in more diffuse and potentially more immature neural networks. Understanding the process bywhich the brain and its cognitive functions mature through healthy adulthood may provide us with new cluesto understanding the vulnerability to neurodevelopmental disorders.en_US
dc.language.isoEnglishen_US
dc.source.titleNeuroImage: Clinicalen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/j.nicl.2015.12.002en_US
dc.subjectBrain activationen_US
dc.subjectfMRIen_US
dc.subjectNeurodevelopmenten_US
dc.subjectNeurodevelopmental disordersen_US
dc.subjectSchizophreniaen_US
dc.subjectWorking memoryen_US
dc.titleWorking memory circuit as a function of increasing age in healthy adolescence: a systematic review and meta-analysesen_US
dc.typeArticleen_US
dc.departmentDepartment of Psychologyen_US
dc.citation.spage940en_US
dc.citation.epage948en_US
dc.citation.volumeNumber12en_US
dc.identifier.doi10.1016/j.nicl.2015.12.002en_US
dc.publisherElsevier Ltden_US
dc.identifier.eissn2213-1582


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