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dc.contributor.authorSever, Melikeen_US
dc.contributor.authorUyan, İdilen_US
dc.contributor.authorTekinay, Ayse B.en_US
dc.contributor.authorGüler, Mustafa O.en_US
dc.contributor.editorZhang, L. G.en_US
dc.contributor.editorKaplan, D. L.en_US
dc.date.accessioned2018-04-12T13:54:09Z
dc.date.available2018-04-12T13:54:09Z
dc.date.issued2016en_US
dc.identifier.isbn9783319314334
dc.identifier.urihttp://hdl.handle.net/11693/38365
dc.descriptionChapter 6en_US
dc.description.abstractNervous system is a highly complex interconnected network and higher organisms including humans have limited neural regeneration capacity. Neurodegenerative diseases result in significant cognitive, sensory, or motor impairments. Following an injury in the neural network, there is a balance between promotion and inhibition of regeneration and this balance is shifted to different directions in central nervous system (CNS) and peripheral nervous system (PNS). More regeneration capacity is observed in the PNS compared to the CNS. Although, several mechanisms play roles in the inhibitory and growth-promoting natures of the CNS and PNS, extracellular matrix (ECM) elements are key players in this process. ECM is a three-dimensional environment where the cells migrate, proliferate, and differentiate (Rutka et al. 1988; Pan et al. 1997). After a comprehensive investigation of the interactions between the ECM proteins and cell receptors, the ECM environment was found to regulate significant cellular processes such as survival, proliferation, differentiation, and migration (Yurchenco and Cheng 1994; Aszodi et al. 2006). Its components have major roles not only in neurogenesis during development of the nervous system but also in normal neural functioning during adulthood (Hubert et al. 2009).en_US
dc.language.isoEnglishen_US
dc.relation.ispartofNeural engineering: From advanced biomaterials to 3D fabrication techniquesen_US
dc.relation.isversionofhttp://doi.org/10.1007/978-3-319-31433-4_6en_US
dc.relation.isversionofhttps://doi.org/10.1007/978-3-319-31433-4en_US
dc.subjectCell membranesen_US
dc.subjectNeurodegenerative diseasesen_US
dc.subjectTissueen_US
dc.subjectCentral nervous systemsen_US
dc.subjectExtracellular matricesen_US
dc.subjectInterconnected networken_US
dc.subjectNeural engineeringen_US
dc.subjectNeural regenerationen_US
dc.subjectPeripheral nervous systemen_US
dc.subjectRegeneration capacityen_US
dc.subjectThree-dimensional environmenten_US
dc.subjectAluminumen_US
dc.titleBioactive nanomaterials for neural engineeringen_US
dc.typeBook Chapteren_US
dc.departmentInstitute of Materials Science and Nanotechnology
dc.departmentNanotechnology Research Centeren_US
dc.citation.spage181en_US
dc.citation.epage206en_US
dc.identifier.doi10.1007/978-3-319-31433-4_6en_US
dc.identifier.doi10.1007/978-3-319-31433-4en_US
dc.publisherSpringer, Chamen_US
dc.identifier.eisbn9783319314310en_US


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