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      Bioactive nanomaterials for neural engineering

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      Author(s)
      Sever, Melike
      Uyan, İdil
      Tekinay, Ayse B.
      Güler, Mustafa O.
      Editor
      Zhang, L. G.
      Kaplan, D. L.
      Date
      2016
      Publisher
      Springer, Cham
      Pages
      181 - 206
      Language
      English
      Type
      Book Chapter
      Item Usage Stats
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      Book Title
      Neural engineering: From advanced biomaterials to 3D fabrication techniques
      Abstract
      Nervous system is a highly complex interconnected network and higher organisms including humans have limited neural regeneration capacity. Neurodegenerative diseases result in significant cognitive, sensory, or motor impairments. Following an injury in the neural network, there is a balance between promotion and inhibition of regeneration and this balance is shifted to different directions in central nervous system (CNS) and peripheral nervous system (PNS). More regeneration capacity is observed in the PNS compared to the CNS. Although, several mechanisms play roles in the inhibitory and growth-promoting natures of the CNS and PNS, extracellular matrix (ECM) elements are key players in this process. ECM is a three-dimensional environment where the cells migrate, proliferate, and differentiate (Rutka et al. 1988; Pan et al. 1997). After a comprehensive investigation of the interactions between the ECM proteins and cell receptors, the ECM environment was found to regulate significant cellular processes such as survival, proliferation, differentiation, and migration (Yurchenco and Cheng 1994; Aszodi et al. 2006). Its components have major roles not only in neurogenesis during development of the nervous system but also in normal neural functioning during adulthood (Hubert et al. 2009).
      Keywords
      Cell membranes
      Neurodegenerative diseases
      Tissue
      Central nervous systems
      Extracellular matrices
      Interconnected network
      Neural engineering
      Neural regeneration
      Peripheral nervous system
      Regeneration capacity
      Three-dimensional environment
      Aluminum
      Permalink
      http://hdl.handle.net/11693/38365
      Published Version (Please cite this version)
      http://doi.org/10.1007/978-3-319-31433-4_6
      https://doi.org/10.1007/978-3-319-31433-4
      Collections
      • Institute of Materials Science and Nanotechnology (UNAM) 2258
      • Nanotechnology Research Center (NANOTAM) 1179
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