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      Biological properties of extracellular vesicles and their physiological functions

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      Author(s)
      Yáñez-Mó, M.
      Siljander, P. R. M.
      Andreu, Z.
      Zavec, A. B.
      Borràs, F. E.
      Buzas, E. I.
      Buzas, K.
      Casal, E.
      Cappello, F.
      Carvalho, J.
      Colás, E.
      Cordeiro-Da, S. A.
      Fais, S.
      Falcon-Perez, J. M.
      Ghobrial, I. M.
      Giebel, B.
      Gimona, M.
      Graner, M.
      Gursel, I.
      Gursel, M.
      Heegaard, N. H. H.
      Hendrix, A.
      Kierulf, P.
      Kokubun, K.
      Kosanovic, M.
      Kralj-Iglic, V.
      Krämer-Albers, E. M.
      Laitinen, S.
      Lässer, C.
      Lener, T.
      Ligeti, E.
      Line, A.
      Lipps, G.
      Llorente, A.
      Lötvall, J.
      Manček-Keber, M.
      Marcilla, A.
      Mittelbrunn, M.
      Nazarenko, I.
      Nolte-'t Hoen, E. N. M.
      Nyman, T. A.
      O'Driscoll, L.
      Olivan, M.
      Oliveira, C.
      Pállinger, E.
      Del Portillo, H. A.
      Reventós, J.
      Rigau, M.
      Rohde, E.
      Sammar, M.
      Sánchez-Madrid, F.
      Santarém, N.
      Schallmoser, K.
      Ostenfeld, M. S.
      Stoorvogel, W.
      Stukelj, R.
      Grein V. D. S.G.
      Helena,ü V. M.
      Wauben, M. H. M.
      De Wever, O.
      Date
      2015
      Source Title
      Journal of Extracellular Vesicles
      Print ISSN
      2001-3078
      Publisher
      Taylor & Francis
      Volume
      4
      Issue
      1
      Pages
      1 - 60
      Language
      English
      Type
      Article
      Item Usage Stats
      221
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      269
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      Abstract
      In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells.While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
      Keywords
      Eukaryote
      Exosome
      Extracellular vesicle
      Microparticle
      Microvesicle
      Physiology
      Prokaryote
      Cytokine
      DNA
      Lectin
      Lipid
      Membrane receptor
      MicroRNA
      Morphogen
      RNA
      Adaptive immunity
      Amnion fluid
      Antigen presenting cell
      Bile
      Biofilm
      Biogenesis
      Biology
      Blood
      Blood clotting
      Body fluid
      Bone mineralization
      Breast milk
      Cell communication
      Cell function
      Cell interaction
      Cell selection
      Cell transport
      Cellular distribution
      Cerebrospinal fluid
      DNA content
      Embryo development
      Exosome
      Feces
      Human
      Innate immunity
      Liver metabolism
      Lung lavage
      Macrophage
      Male genital system
      Mast cell
      Membrane vesicle
      Mesenchymal stem cell
      Microorganism
      Molecular biology
      Monocyte
      Natural killer cell
      Nervous system
      Neutrophil
      Nonhuman
      Nose mucus
      Plant
      Pregnancy
      Protein glycosylation
      Protein processing
      Proteomics
      Reticulocyte
      Review
      RNA analysis
      RNA transport
      Saliva
      Seminal plasma
      Stress
      Synovial fluid
      T lymphocyte
      Tissue repair
      Urine
      Uterus fluid
      Vascular biology
      Eukaryota
      Prokaryota
      Permalink
      http://hdl.handle.net/11693/38337
      Published Version (Please cite this version)
      http://dx.doi.org/10.3402/jev.v4.27066
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