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dc.contributor.authorFerrazzoli, D.en_US
dc.contributor.authorCarter, A.en_US
dc.contributor.authorUstun, F. S.en_US
dc.contributor.authorPalamara, G.en_US
dc.contributor.authorOrtelli, P.en_US
dc.contributor.authorMaestri, R.en_US
dc.contributor.authorYucel, M.en_US
dc.contributor.authorFrazzitta, G.en_US
dc.date.accessioned2018-04-12T13:53:05Z
dc.date.available2018-04-12T13:53:05Z
dc.date.issued2016en_US
dc.identifier.urihttp://hdl.handle.net/11693/38332
dc.description.abstractThe principal feature of Parkinson’s disease (PD) is the impaired ability to acquire and express habitual-automatic actions due to the loss of dopamine in the dorsolateral striatum, the region of the basal ganglia associated with the control of habitual behavior. Dopamine replacement therapy (DRT) compensates for the lack of dopamine, representing the standard treatment for different motor symptoms of PD (such as rigidity, bradykinesia and resting tremor). On the other hand, rehabilitation treatments, exploiting the use of cognitive strategies, feedbacks and external cues, permit to “learn to bypass” the defective basal ganglia (using the dorsolateral area of the prefrontal cortex) allowing the patients to perform correct movements under executive-volitional control. Therefore, DRT and rehabilitation seem to be two complementary and synergistic approaches. Learning and reward are central in rehabilitation: both of these mechanisms are the basis for the success of any rehabilitative treatment. Anyway, it is known that “learning resources” and reward could be negatively influenced from dopaminergic drugs. Furthermore, DRT causes different well-known complications: among these, dyskinesias, motor fluctuations, and dopamine dysregulation syndrome (DDS) are intimately linked with the alteration in the learning and reward mechanisms and could impact seriously on the rehabilitative outcomes. These considerations highlight the need for careful titration of DRT to produce the desired improvement in motor symptoms while minimizing the associated detrimental effects. This is important in order to maximize the motor re-learning based on repetition, reward and practice during rehabilitation. In this scenario, we review the knowledge concerning the interactions between DRT, learning and reward, examine the most impactful DRT side effects and provide suggestions for optimizing rehabilitation in PD.en_US
dc.language.isoEnglishen_US
dc.source.titleFrontiers in Behavioral Neuroscienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.3389/fnbeh.2016.00121en_US
dc.subjectDopamine replacement therapyen_US
dc.subjectDRT side effectsen_US
dc.subjectLearningen_US
dc.subjectRehabilitationen_US
dc.subjectReward predictionen_US
dc.subjectDopamine 1 receptoren_US
dc.subjectDopamine receptor stimulating agenten_US
dc.subjectLevodopaen_US
dc.subjectAkathisiaen_US
dc.subjectBasal ganglionen_US
dc.subjectBrain diseaseen_US
dc.subjectChoreaen_US
dc.subjectChoreoathetosisen_US
dc.subjectDopamine dysregulation syndromeen_US
dc.subjectDopamine releaseen_US
dc.subjectDopamine replacement therapyen_US
dc.subjectDopaminergic systemen_US
dc.subjectDrug dose titrationen_US
dc.subjectDrug therapyen_US
dc.subjectDyskinesiaen_US
dc.subjectExecutive functionen_US
dc.subjectExercise intensityen_US
dc.subjectHumanen_US
dc.subjectLearningen_US
dc.subjectMotivationen_US
dc.subjectMotor controlen_US
dc.subjectMotor dysfunctionen_US
dc.subjectMotor fluctuationen_US
dc.subjectMyoclonusen_US
dc.subjectNerve cell plasticityen_US
dc.subjectNonhumanen_US
dc.subjectParkinson diseaseen_US
dc.subjectPrefrontal cortexen_US
dc.subjectResistance trainingen_US
dc.subjectReviewen_US
dc.subjectRewarden_US
dc.subjectTreadmill exerciseen_US
dc.titleDopamine replacement therapy, learning and reward prediction in Parkinson’s disease: Implications for rehabilitationen_US
dc.typeReviewen_US
dc.departmentInstitute of Materials Science and Nanotechnology (UNAM)en_US
dc.citation.spage1en_US
dc.citation.epage8en_US
dc.citation.volumeNumber10en_US
dc.citation.issueNumber121en_US
dc.identifier.doi10.3389/fnbeh.2016.00121en_US
dc.publisherFrontiers Research Foundationen_US
dc.identifier.eissn1662-5153en_US


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