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dc.contributor.authorLeong, S. C.en_US
dc.contributor.authorKathan, C.en_US
dc.contributor.authorMortimore, S.en_US
dc.date.accessioned2018-04-12T13:45:43Z
dc.date.available2018-04-12T13:45:43Z
dc.date.issued2010en_US
dc.identifier.issn0022-2151
dc.identifier.urihttp://hdl.handle.net/11693/38148
dc.description.abstractObjectives: To review early oncological outcomes following transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma. Design: Retrospective review of hospital electronic database. Setting: Large district general hospital in England, UK.Main outcome measures: Patients' three-year disease-specific survival and disease-free survival were evaluated, including post-operative complications, voice quality and swallowing status. Results: Seventy-seven patients (16 women and 61 men) were identified. Transoral laser excision of squamous cell carcinoma of the larynx was undergone by 65 patients, and the same procedure in the hypopharynx by 12. Patients with laryngeal cancer had statistically better disease-specific survival than those with hypopharyngeal cancer (p=0.021), although the cumulative disease-free survival probability was 0.71 for both larynx and hypopharynx groups. Patients who underwent laryngectomy following failed laser treatment or as a salvage procedure had poorer outcomes.Conclusions: The overall results of this study were comparable with those of other, larger studies. At three-year follow up, cumulative disease-specific survival probabilities were 0.92 and 0.71 for laryngeal and hypopharyngeal squamous cell carcinoma, respectively. Copyright © JLO (1984) Limited 2009.en_US
dc.language.isoEnglishen_US
dc.source.titleJournal of Laryngology and Otologyen_US
dc.relation.isversionofhttp://dx.doi.org/10.1017/S0022215109991514en_US
dc.subjectLarynx neoplasmsen_US
dc.subjectLaser therapyen_US
dc.subjectPharynx neoplasmsen_US
dc.subjectAdulten_US
dc.subjectCarbon dioxide laseren_US
dc.subjectControlled studyen_US
dc.subjectDisease free survivalen_US
dc.subjectFemaleen_US
dc.subjectFollow upen_US
dc.subjectHumanen_US
dc.subjectHypopharynx carcinomaen_US
dc.subjectLaryngectomyen_US
dc.subjectLarynx carcinomaen_US
dc.subjectMajor clinical studyen_US
dc.subjectMaleen_US
dc.subjectOutcome assessmenten_US
dc.subjectOverall survivalen_US
dc.subjectPostoperative complicationen_US
dc.subjectRetrospective studyen_US
dc.subjectReviewen_US
dc.subjectSalvage therapyen_US
dc.subjectSquamous cell carcinomaen_US
dc.subjectSurvival rateen_US
dc.subjectSwallowingen_US
dc.subjectTreatment outcomeen_US
dc.subjectUnited Kingdomen_US
dc.subjectVoiceen_US
dc.subjectAgeden_US
dc.subjectAged, 80 and overen_US
dc.subjectCarcinoma, Squamous Cellen_US
dc.subjectDisease-Free Survivalen_US
dc.subjectEnglanden_US
dc.subjectHypopharyngeal Neoplasmsen_US
dc.subjectLaryngeal Neoplasmsen_US
dc.subjectLaser Therapyen_US
dc.subjectLasers, Gasen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectNeoplasm Recurrence, Localen_US
dc.subjectOutcome Assessment (Health Care)en_US
dc.subjectRetrospective Studiesen_US
dc.subjectSurvival Analysisen_US
dc.titleEarly outcomes after transoral CO2 laser resection of laryngeal and hypopharyngeal squamous cell carcinoma: One centre's experienceen_US
dc.typeReviewen_US
dc.departmentDepartment of Economicsen_US
dc.citation.spage185en_US
dc.citation.epage193en_US
dc.citation.volumeNumber124en_US
dc.citation.issueNumber2en_US
dc.identifier.doi10.1017/S0022215109991514en_US
dc.publisherCambridge University Pressen_US


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